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A6W1R4

- TYSY_MARMS

UniProt

A6W1R4 - TYSY_MARMS

Protein

Thymidylate synthase

Gene

thyA

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei160 – 1601UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciMSP400668:GHKD-3824-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:Mmwyl1_3742
    OrganismiMarinomonas sp. (strain MWYL1)
    Taxonomic identifieri400668 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
    ProteomesiUP000001113: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Thymidylate synthasePRO_1000073878Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi400668.Mmwyl1_3742.

    Structurei

    3D structure databases

    ProteinModelPortaliA6W1R4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257900.
    KOiK00560.
    OMAiDVHLYSN.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6W1R4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQYLDLCNR IVNEGEWVSN ERTGKRCLTV INADLTYDVS KGEFPLVTTR    50
    KSYWKSAIAE IIGYLRGYDN AADFRALGTK TWDANANENE VWLNSPYRKG 100
    EDDMGLCYGA IGRNFPKPDG GHIDLLKQII DDLSRGVDNR GEILTFYHPG 150
    AFHMACLRPC MYSHHFSLLG DTLYLNSTQR SCDVPLGLNF NMVQVYVLLA 200
    IVAQITGKKP GKAFHKIVNA HIYEDQLELM RDVQLKREPY PLPTLKINPE 250
    IKSLKDIETW VTMDDFEIEG YQFHEPIAYP FSV 283
    Length:283
    Mass (Da):32,366
    Last modified:August 21, 2007 - v1
    Checksum:iD29135848F985CEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000749 Genomic DNA. Translation: ABR72643.1.
    RefSeqiWP_012071408.1. NC_009654.1.
    YP_001342578.1. NC_009654.1.

    Genome annotation databases

    EnsemblBacteriaiABR72643; ABR72643; Mmwyl1_3742.
    GeneIDi5366180.
    KEGGimmw:Mmwyl1_3742.
    PATRICi22471085. VBIMarSp124341_3874.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000749 Genomic DNA. Translation: ABR72643.1 .
    RefSeqi WP_012071408.1. NC_009654.1.
    YP_001342578.1. NC_009654.1.

    3D structure databases

    ProteinModelPortali A6W1R4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 400668.Mmwyl1_3742.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR72643 ; ABR72643 ; Mmwyl1_3742 .
    GeneIDi 5366180.
    KEGGi mmw:Mmwyl1_3742.
    PATRICi 22471085. VBIMarSp124341_3874.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257900.
    KOi K00560.
    OMAi DVHLYSN.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci MSP400668:GHKD-3824-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MWYL1.

    Entry informationi

    Entry nameiTYSY_MARMS
    AccessioniPrimary (citable) accession number: A6W1R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3