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A6W1J2 (A6W1J2_MARMS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
EC=1.2.1.71 HAMAP MF_01174
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase HAMAP MF_01174
Gene names
Name:astD HAMAP MF_01174
Ordered Locus Names:Mmwyl1_3670
OrganismMarinomonas sp. (strain MWYL1) [Complete proteome] [HAMAP] EMBL ABR72571.1
Taxonomic identifier400668 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Marinomonas

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily. HAMAP MF_01174

Ontologies

Keywords
   Biological processArginine metabolism HAMAP MF_01174
   LigandNAD HAMAP MF_01174
   Molecular functionOxidoreductase HAMAP MF_01174
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process to glutamate

Inferred from electronic annotation. Source: HAMAP

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding222 – 2276NAD By similarity HAMAP MF_01174

Sites

Active site2451 By similarity HAMAP MF_01174
Active site2801 By similarity HAMAP MF_01174

Sequences

Sequence LengthMass (Da)Tools
A6W1J2 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: EB5766220CA95899

FASTA49052,380
        10         20         30         40         50         60 
MKQAHYINGQ WLAGEGQLLS SIDPADASLV WQANAATSDQ VGLAIQAARS AFPAWANRPL 

        70         80         90        100        110        120 
EERLTVIEAF AELIKEHSED IATIISRETG KPIWETRTEA AAMVGKVAIS KQAYHERTGE 

       130        140        150        160        170        180 
KTTPMPGATA RLRHRPHGVV AVFGPYNFPG HLPNGHIVPA LIAGNTVVFK PSEQAPATSD 

       190        200        210        220        230        240 
LIIQLWGKAG LPAGVVNLIQ GERDTGVALA NHQGIDGLFF TGSPQVGHIL HKDFAGHPGK 

       250        260        270        280        290        300 
ILALEMGGNN PLLVSEKIAD QRAAVHEIIQ SAFISAGQRC TCARRLLLPK GALGDAILQS 

       310        320        330        340        350        360 
LVTATKALKI DRYDAEEQPF MGPIVSAQAA DGLLQAYQKL IDLGASPIVE MTRGDSQTGF 

       370        380        390        400        410        420 
VTPGIIDATD ILDELPDQEY FGPLLTVIRY DSLEQAMTIA NNTKFGLSAG ILSDDVDEYE 

       430        440        450        460        470        480 
WFLQHSRAGI INWNRQTTGA SSNAPFGGTG ASGNHRASAY YAADYCAYPV ASIEADSLTM 

       490 
PEKLGHGITL

« Hide

References

[1]"Complete sequence of Marinomonas sp. MWYL1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Johnston A.W.B., Todd J.D., Rogers R., Wexler M., Bond P.L., Li Y., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MWYL1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000749 Genomic DNA. Translation: ABR72571.1.
RefSeqYP_001342506.1. NC_009654.1.

3D structure databases

ProteinModelPortalA6W1J2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6W1J2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5369101.
GenomeReviewsGene locus Mmwyl1_3670 in contig CP000749_GR.
KEGGmmw:Mmwyl1_3670.
PATRIC22470935. VBIMarSp124341_3799.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAIRAHDER.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6W1J2_MARMS
AccessionPrimary (citable) accession number: A6W1J2
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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