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Protein

Argininosuccinate lyase

Gene

argH

Organism
Marinomonas sp. (strain MWYL1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMSP400668:GHKD-3659-MONOMER.
UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Mmwyl1_3590Imported
OrganismiMarinomonas sp. (strain MWYL1)Imported
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
Proteomesi
  • UP000001113 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_3590.

Structurei

3D structure databases

ProteinModelPortaliA6W1B3.
SMRiA6W1B3. Positions 21-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 308295Lyase_1InterPro annotationAdd
BLAST
Domaini371 – 43969ASL_C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiGRGKMER.
OrthoDBiEOG6P5ZF8.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6W1B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTNKTTNQ QWGGRFSEPV DAFVARFTAS VEFDQRMAKQ DIQGSIAHGK
60 70 80 90 100
MLASVGVLTE EERDQIIQGL TEIEDEIARG EFEWSVELED VHMNIEARLT
110 120 130 140 150
QKIGITGKKL HTGRSRNDQV ATDIRLYMRD EVDFLLEEVT RLQQGILSLA
160 170 180 190 200
EKEANTIMPG FTHLQTAQPV TFGHHLMAWY EMMQRDYERL VDCRKRINIL
210 220 230 240 250
PLGAAALAGT TYPIDRHMTA ELLGFERPTY NSLDSVSDRD FAIEFTATAS
260 270 280 290 300
IIMMHLSRWA EEMVMWVSAQ FNFIYLPDRF CTGSSIMPQK KNPDVPELVR
310 320 330 340 350
GKTGRVYGHL MGLLTLMKSQ CLAYNKDNQE DKEPLFDTVD TLKGSLRAFA
360 370 380 390 400
DMIPAIESRK EHMYEAARRG FSTATDLADY LVRHGVAFRD AHEVVGKAVG
410 420 430 440 450
YGVKEGKDLS EMTLEELQSF GSMIEADVFD VLTLEGSVAA RNHIGGTAPA
460
QVLKAVERAK ADLTTR
Length:466
Mass (Da):52,447
Last modified:August 21, 2007 - v1
Checksum:i09D141823054CCE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR72492.1.
RefSeqiWP_012071257.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR72492; ABR72492; Mmwyl1_3590.
KEGGimmw:Mmwyl1_3590.
PATRICi22470741. VBIMarSp124341_3715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR72492.1.
RefSeqiWP_012071257.1. NC_009654.1.

3D structure databases

ProteinModelPortaliA6W1B3.
SMRiA6W1B3. Positions 21-464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi400668.Mmwyl1_3590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR72492; ABR72492; Mmwyl1_3590.
KEGGimmw:Mmwyl1_3590.
PATRICi22470741. VBIMarSp124341_3715.

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiGRGKMER.
OrthoDBiEOG6P5ZF8.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.
BioCyciMSP400668:GHKD-3659-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MWYL1Imported.

Entry informationi

Entry nameiA6W1B3_MARMS
AccessioniPrimary (citable) accession number: A6W1B3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.