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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processBiotin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMSP400668:G1G9E-3567-MONOMER
UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:Mmwyl1_3454
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesOceanospirillaceaeMarinomonas
Proteomesi
  • UP000001113 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004125101 – 270Malonyl-[acyl-carrier protein] O-methyltransferaseAdd BLAST270

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_3454

Structurei

3D structure databases

ProteinModelPortaliA6W0X8
SMRiA6W0X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410626R Bacteria
COG0500 LUCA
HOGENOMiHOG000265010
KOiK02169
OMAiATYQVVY
OrthoDBiPOG091H05JY

Family and domain databases

HAMAPiMF_00835 BioC, 1 hit
InterProiView protein in InterPro
IPR011814 BioC
IPR013216 Methyltransf_11
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02072 BioC, 1 hit

Sequencei

Sequence statusi: Complete.

A6W0X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLITPDISAL SYKRQLAKRF DRASQSYDSY ADFQKVVLER LLAMLPLNQA
60 70 80 90 100
DVVLDLGTGT GQALGILSER LNPKCNIALD LSLQMLAVAS ERFSSLHNTH
110 120 130 140 150
YVCADAERLP LQDRSCDLVF SSLAIQWCLS PLDLFKELYR VIKPGGYVVF
160 170 180 190 200
STLSQGSMPE ISKAWFGLDN KEHVHQYMAS DALLDSIRAS ELNLLSSQLS
210 220 230 240 250
NISMWFDSPE SAIYSLKKVG ASLIASDGDP SVSPSKWKAF LLEYEKQRNE
260 270
LGIPLSYQVS FVVAQRPNSI
Length:270
Mass (Da):30,062
Last modified:August 21, 2007 - v1
Checksum:iBA2830C808919A4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA Translation: ABR72357.1
RefSeqiWP_012071124.1, NC_009654.1

Genome annotation databases

EnsemblBacteriaiABR72357; ABR72357; Mmwyl1_3454
KEGGimmw:Mmwyl1_3454

Similar proteinsi

Entry informationi

Entry nameiBIOC_MARMS
AccessioniPrimary (citable) accession number: A6W0X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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