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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMSP400668:GHKD-3523-MONOMER.
UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:Mmwyl1_3454
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
Proteomesi
  • UP000001113 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Malonyl-[acyl-carrier protein] O-methyltransferasePRO_0000412510Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_3454.

Structurei

3D structure databases

ProteinModelPortaliA6W0X8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410626R. Bacteria.
COG0500. LUCA.
HOGENOMiHOG000265010.
KOiK02169.
OMAiLVHVNRF.
OrthoDBiPOG091H05JY.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00835. BioC. 1 hit.
InterProiIPR011814. BioC.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02072. BioC. 1 hit.

Sequencei

Sequence statusi: Complete.

A6W0X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLITPDISAL SYKRQLAKRF DRASQSYDSY ADFQKVVLER LLAMLPLNQA
60 70 80 90 100
DVVLDLGTGT GQALGILSER LNPKCNIALD LSLQMLAVAS ERFSSLHNTH
110 120 130 140 150
YVCADAERLP LQDRSCDLVF SSLAIQWCLS PLDLFKELYR VIKPGGYVVF
160 170 180 190 200
STLSQGSMPE ISKAWFGLDN KEHVHQYMAS DALLDSIRAS ELNLLSSQLS
210 220 230 240 250
NISMWFDSPE SAIYSLKKVG ASLIASDGDP SVSPSKWKAF LLEYEKQRNE
260 270
LGIPLSYQVS FVVAQRPNSI
Length:270
Mass (Da):30,062
Last modified:August 21, 2007 - v1
Checksum:iBA2830C808919A4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR72357.1.
RefSeqiWP_012071124.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR72357; ABR72357; Mmwyl1_3454.
KEGGimmw:Mmwyl1_3454.
PATRICi22470453. VBIMarSp124341_3571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR72357.1.
RefSeqiWP_012071124.1. NC_009654.1.

3D structure databases

ProteinModelPortaliA6W0X8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi400668.Mmwyl1_3454.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR72357; ABR72357; Mmwyl1_3454.
KEGGimmw:Mmwyl1_3454.
PATRICi22470453. VBIMarSp124341_3571.

Phylogenomic databases

eggNOGiENOG410626R. Bacteria.
COG0500. LUCA.
HOGENOMiHOG000265010.
KOiK02169.
OMAiLVHVNRF.
OrthoDBiPOG091H05JY.

Enzyme and pathway databases

UniPathwayiUPA00078.
BioCyciMSP400668:GHKD-3523-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00835. BioC. 1 hit.
InterProiIPR011814. BioC.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02072. BioC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBIOC_MARMS
AccessioniPrimary (citable) accession number: A6W0X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.