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A6VZE7

- SYL_MARMS

UniProt

A6VZE7 - SYL_MARMS

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Protein

Leucine--tRNA ligase

Gene
leuS, Mmwyl1_2915
Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei577 – 5771ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP400668:GHKD-2977-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Mmwyl1_2915
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
ProteomesiUP000001113: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Leucine--tRNA ligaseUniRule annotationPRO_1000074837Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_2915.

Structurei

3D structure databases

ProteinModelPortaliA6VZE7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi574 – 5785"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VZE7-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYNPQQI EQAAQSFWDE NKVFKAIADS SKEKFYCLSM FPYPSGRLHM    50
GHVRNYTIGD VISRYQRMQG KNVLQPMGWD AFGLPAENAA IKHKTAPAKW 100
TTENIAYMKG QLKELGFGYD WDREIATCTP EYYKWEQWFF TQLVEKGLAY 150
KKTAAVNWCP EDQTVLANEQ VEDGCCWRCG TNVEKKEISQ WFIRITDYAE 200
ELLNDLDQLD GWPEKVKAMQ RNWIGRSEGL EFSFAVEGKD ERLSVYTTRP 250
DTIMGVTYVA VATQHPLSLE ASANNADLAA FIEESKKMST TEADMATVEK 300
KGMDTGFKAI HPITGEAVPV YAANFVLMDY GSGAVMSVPA HDQRDFEFAK 350
KYNLAIKQVV QPAGDEVIDL EKAAFTEKGV LCNSGEFDGL AFKEAFDAIA 400
AWMVERNLGE VKVNYRLRDW GVSRQRYWGT PIPTINLKDG SVVPVPQDQL 450
PVELPTDVIM DGVNSPIKNN PDFSSIMFNG EEAERETDTF DTFMESSWYF 500
ARYCCPDSTD AMLTEEANYW LPVDQYVGGV EHAILHLLYS RFFHKLLRDA 550
GLVNSDEPFK RLLTQGMVNK DGTKMSKSKG NTVDPQEMIE KYGADTVRLF 600
MMFSAPPEQS LEWNDAGVDG ASRFLRRLWA LSYRHTNAGK VGELNIAELN 650
GAQKALRRKT HETIQKVSDD IERRQTFNTA IAAVMELCNE ISKFEDSSEL 700
GLAVEQEALE AATLLLSPIV PHIAHQLWSE LGHSDNIVNT PWPTLDEEAL 750
IKDELTIVVQ VLGKKRAELT VSANADNKTI EAEALAHPSV AKLLEGKTVR 800
KVIVVPGRLV NIVAN 815
Length:815
Mass (Da):91,770
Last modified:August 21, 2007 - v1
Checksum:iA883C6875172BEBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR71826.1.
RefSeqiWP_012070602.1. NC_009654.1.
YP_001341761.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR71826; ABR71826; Mmwyl1_2915.
GeneIDi5369106.
KEGGimmw:Mmwyl1_2915.
PATRICi22469329. VBIMarSp124341_3016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000749 Genomic DNA. Translation: ABR71826.1 .
RefSeqi WP_012070602.1. NC_009654.1.
YP_001341761.1. NC_009654.1.

3D structure databases

ProteinModelPortali A6VZE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400668.Mmwyl1_2915.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR71826 ; ABR71826 ; Mmwyl1_2915 .
GeneIDi 5369106.
KEGGi mmw:Mmwyl1_2915.
PATRICi 22469329. VBIMarSp124341_3016.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MSP400668:GHKD-2977-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MWYL1.

Entry informationi

Entry nameiSYL_MARMS
AccessioniPrimary (citable) accession number: A6VZE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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