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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei577 – 5771ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP400668:GHKD-2977-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mmwyl1_2915
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
ProteomesiUP000001113 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Leucine--tRNA ligasePRO_1000074837Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_2915.

Structurei

3D structure databases

ProteinModelPortaliA6VZE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi574 – 5785"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VZE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYNPQQI EQAAQSFWDE NKVFKAIADS SKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMQG KNVLQPMGWD AFGLPAENAA IKHKTAPAKW
110 120 130 140 150
TTENIAYMKG QLKELGFGYD WDREIATCTP EYYKWEQWFF TQLVEKGLAY
160 170 180 190 200
KKTAAVNWCP EDQTVLANEQ VEDGCCWRCG TNVEKKEISQ WFIRITDYAE
210 220 230 240 250
ELLNDLDQLD GWPEKVKAMQ RNWIGRSEGL EFSFAVEGKD ERLSVYTTRP
260 270 280 290 300
DTIMGVTYVA VATQHPLSLE ASANNADLAA FIEESKKMST TEADMATVEK
310 320 330 340 350
KGMDTGFKAI HPITGEAVPV YAANFVLMDY GSGAVMSVPA HDQRDFEFAK
360 370 380 390 400
KYNLAIKQVV QPAGDEVIDL EKAAFTEKGV LCNSGEFDGL AFKEAFDAIA
410 420 430 440 450
AWMVERNLGE VKVNYRLRDW GVSRQRYWGT PIPTINLKDG SVVPVPQDQL
460 470 480 490 500
PVELPTDVIM DGVNSPIKNN PDFSSIMFNG EEAERETDTF DTFMESSWYF
510 520 530 540 550
ARYCCPDSTD AMLTEEANYW LPVDQYVGGV EHAILHLLYS RFFHKLLRDA
560 570 580 590 600
GLVNSDEPFK RLLTQGMVNK DGTKMSKSKG NTVDPQEMIE KYGADTVRLF
610 620 630 640 650
MMFSAPPEQS LEWNDAGVDG ASRFLRRLWA LSYRHTNAGK VGELNIAELN
660 670 680 690 700
GAQKALRRKT HETIQKVSDD IERRQTFNTA IAAVMELCNE ISKFEDSSEL
710 720 730 740 750
GLAVEQEALE AATLLLSPIV PHIAHQLWSE LGHSDNIVNT PWPTLDEEAL
760 770 780 790 800
IKDELTIVVQ VLGKKRAELT VSANADNKTI EAEALAHPSV AKLLEGKTVR
810
KVIVVPGRLV NIVAN
Length:815
Mass (Da):91,770
Last modified:August 21, 2007 - v1
Checksum:iA883C6875172BEBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR71826.1.

Genome annotation databases

EnsemblBacteriaiABR71826; ABR71826; Mmwyl1_2915.
PATRICi22469329. VBIMarSp124341_3016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR71826.1.

3D structure databases

ProteinModelPortaliA6VZE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi400668.Mmwyl1_2915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR71826; ABR71826; Mmwyl1_2915.
PATRICi22469329. VBIMarSp124341_3016.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciMSP400668:GHKD-2977-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MWYL1.

Entry informationi

Entry nameiSYL_MARMS
AccessioniPrimary (citable) accession number: A6VZE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: July 22, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.