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A6VZE7 (SYL_MARMS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Mmwyl1_2915
OrganismMarinomonas sp. (strain MWYL1) [Complete proteome] [HAMAP]
Taxonomic identifier400668 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas

Protein attributes

Sequence length815 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 815815Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000074837

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif574 – 5785"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5771ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6VZE7 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: A883C6875172BEBB

FASTA81591,770
        10         20         30         40         50         60 
MQEQYNPQQI EQAAQSFWDE NKVFKAIADS SKEKFYCLSM FPYPSGRLHM GHVRNYTIGD 

        70         80         90        100        110        120 
VISRYQRMQG KNVLQPMGWD AFGLPAENAA IKHKTAPAKW TTENIAYMKG QLKELGFGYD 

       130        140        150        160        170        180 
WDREIATCTP EYYKWEQWFF TQLVEKGLAY KKTAAVNWCP EDQTVLANEQ VEDGCCWRCG 

       190        200        210        220        230        240 
TNVEKKEISQ WFIRITDYAE ELLNDLDQLD GWPEKVKAMQ RNWIGRSEGL EFSFAVEGKD 

       250        260        270        280        290        300 
ERLSVYTTRP DTIMGVTYVA VATQHPLSLE ASANNADLAA FIEESKKMST TEADMATVEK 

       310        320        330        340        350        360 
KGMDTGFKAI HPITGEAVPV YAANFVLMDY GSGAVMSVPA HDQRDFEFAK KYNLAIKQVV 

       370        380        390        400        410        420 
QPAGDEVIDL EKAAFTEKGV LCNSGEFDGL AFKEAFDAIA AWMVERNLGE VKVNYRLRDW 

       430        440        450        460        470        480 
GVSRQRYWGT PIPTINLKDG SVVPVPQDQL PVELPTDVIM DGVNSPIKNN PDFSSIMFNG 

       490        500        510        520        530        540 
EEAERETDTF DTFMESSWYF ARYCCPDSTD AMLTEEANYW LPVDQYVGGV EHAILHLLYS 

       550        560        570        580        590        600 
RFFHKLLRDA GLVNSDEPFK RLLTQGMVNK DGTKMSKSKG NTVDPQEMIE KYGADTVRLF 

       610        620        630        640        650        660 
MMFSAPPEQS LEWNDAGVDG ASRFLRRLWA LSYRHTNAGK VGELNIAELN GAQKALRRKT 

       670        680        690        700        710        720 
HETIQKVSDD IERRQTFNTA IAAVMELCNE ISKFEDSSEL GLAVEQEALE AATLLLSPIV 

       730        740        750        760        770        780 
PHIAHQLWSE LGHSDNIVNT PWPTLDEEAL IKDELTIVVQ VLGKKRAELT VSANADNKTI 

       790        800        810 
EAEALAHPSV AKLLEGKTVR KVIVVPGRLV NIVAN 

« Hide

References

[1]"Complete sequence of Marinomonas sp. MWYL1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Johnston A.W.B., Todd J.D., Rogers R., Wexler M., Bond P.L., Li Y., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MWYL1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000749 Genomic DNA. Translation: ABR71826.1.
RefSeqYP_001341761.1. NC_009654.1.

3D structure databases

ProteinModelPortalA6VZE7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING400668.Mmwyl1_2915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR71826; ABR71826; Mmwyl1_2915.
GeneID5369106.
KEGGmmw:Mmwyl1_2915.
PATRIC22469329. VBIMarSp124341_3016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycMSP400668:GHKD-2977-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_MARMS
AccessionPrimary (citable) accession number: A6VZE7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries