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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei577ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP400668:G1G9E-3016-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mmwyl1_2915
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesOceanospirillaceaeMarinomonas
Proteomesi
  • UP000001113 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000748371 – 815Leucine--tRNA ligaseAdd BLAST815

Proteomic databases

PRIDEiA6VZE7

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_2915

Structurei

3D structure databases

ProteinModelPortaliA6VZE7
SMRiA6VZE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi574 – 578"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A6VZE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYNPQQI EQAAQSFWDE NKVFKAIADS SKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMQG KNVLQPMGWD AFGLPAENAA IKHKTAPAKW
110 120 130 140 150
TTENIAYMKG QLKELGFGYD WDREIATCTP EYYKWEQWFF TQLVEKGLAY
160 170 180 190 200
KKTAAVNWCP EDQTVLANEQ VEDGCCWRCG TNVEKKEISQ WFIRITDYAE
210 220 230 240 250
ELLNDLDQLD GWPEKVKAMQ RNWIGRSEGL EFSFAVEGKD ERLSVYTTRP
260 270 280 290 300
DTIMGVTYVA VATQHPLSLE ASANNADLAA FIEESKKMST TEADMATVEK
310 320 330 340 350
KGMDTGFKAI HPITGEAVPV YAANFVLMDY GSGAVMSVPA HDQRDFEFAK
360 370 380 390 400
KYNLAIKQVV QPAGDEVIDL EKAAFTEKGV LCNSGEFDGL AFKEAFDAIA
410 420 430 440 450
AWMVERNLGE VKVNYRLRDW GVSRQRYWGT PIPTINLKDG SVVPVPQDQL
460 470 480 490 500
PVELPTDVIM DGVNSPIKNN PDFSSIMFNG EEAERETDTF DTFMESSWYF
510 520 530 540 550
ARYCCPDSTD AMLTEEANYW LPVDQYVGGV EHAILHLLYS RFFHKLLRDA
560 570 580 590 600
GLVNSDEPFK RLLTQGMVNK DGTKMSKSKG NTVDPQEMIE KYGADTVRLF
610 620 630 640 650
MMFSAPPEQS LEWNDAGVDG ASRFLRRLWA LSYRHTNAGK VGELNIAELN
660 670 680 690 700
GAQKALRRKT HETIQKVSDD IERRQTFNTA IAAVMELCNE ISKFEDSSEL
710 720 730 740 750
GLAVEQEALE AATLLLSPIV PHIAHQLWSE LGHSDNIVNT PWPTLDEEAL
760 770 780 790 800
IKDELTIVVQ VLGKKRAELT VSANADNKTI EAEALAHPSV AKLLEGKTVR
810
KVIVVPGRLV NIVAN
Length:815
Mass (Da):91,770
Last modified:August 21, 2007 - v1
Checksum:iA883C6875172BEBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA Translation: ABR71826.1
RefSeqiWP_012070602.1, NC_009654.1

Genome annotation databases

EnsemblBacteriaiABR71826; ABR71826; Mmwyl1_2915
KEGGimmw:Mmwyl1_2915

Similar proteinsi

Entry informationi

Entry nameiSYL_MARMS
AccessioniPrimary (citable) accession number: A6VZE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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