Reviewed, UniProtKB/Swiss-Prot A6VZ12 (UXUA_MARMS)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	Mmwyl1_2778

Organism

Marinomonas sp. (strain MWYL1) [Complete proteome] [HAMAP]

Taxonomic identifier

400668 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Marinomonas

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Mannonate dehydratase HAMAP MF_00106		PRO_1000075902

Sequences

	Sequence		Length	Mass (Da)
	A6VZ12-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 54FF68FF2EED826E	FASTA	391	44,006
	10 20 30 40 50 60 MEHTWRWFGP NDETTLTDIR QTGATGVVTA LHEIPNGEVW PVEAIKARKA MIEAHTLRWS 70 80 90 100 110 120 VVESVPVHED IKKRTGNYQE YIQNYKQTLL NLAECGIDTV CYNFMPVLDW TRTDLDYELP 130 140 150 160 170 180 DGSRALRFDQ TAFAAFELYI LERKGAESEY SDEEKAQAKI FLENLKAEDK DRLVANIIAG 190 200 210 220 230 240 LPGSEESYTI EQFREKLDEY AGIDKDKLRE HLKLFLEEIV PAAEQGGLRL AIHPDDPPRP 250 260 270 280 290 300 ILGLPRVVSV KDDIEWLLGA VPSPVNGITL CTGSYGVRAD NDLVDMVQRF GSNIFFTHLR 310 320 330 340 350 360 STKREEVAGS FHEASHLGGD VDMVGVVRAL LVEEKKRNDN NAPSLIPMRP DHGHQILNDL 370 380 390 EKNSKPGYSK LGRMKGLAEV RGLELGLKST L

References

[1]

"Complete sequence of Marinomonas sp. MWYL1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Johnston A.W.B., Todd J.D., Rogers R., Wexler M., Bond P.L., Li Y., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000749 Genomic DNA. Translation: ABR71691.1.
RefSeq	YP_001341626.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VZ12.
Genome annotation databases
GeneID	5368020.
GenomeReviews	Gene locus Mmwyl1_2778 in contig CP000749_GR.
KEGG	mmw:Mmwyl1_2778.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VHEEIKT.
Family and domain databases
HAMAP	MF_00106. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
ProDom	PD002300. THFDhg/Cyc_hydro. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_MARMS

Accession

Primary (citable) accession number: A6VZ12

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)