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Protein

NAD kinase

Gene

nadK

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton acceptorUniRule annotation1
Binding sitei157NADUniRule annotation1
Binding sitei174NADUniRule annotation1
Binding sitei176NADUniRule annotation1
Binding sitei247NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 73NADUniRule annotation2
Nucleotide bindingi146 – 147NADUniRule annotation2
Nucleotide bindingi187 – 192NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP400668:G1G9E-2219-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Mmwyl1_2163
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesOceanospirillaceaeMarinomonas
Proteomesi
  • UP000001113 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000795011 – 293NAD kinaseAdd BLAST293

Proteomic databases

PRIDEiA6VXA6

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_2163

Structurei

3D structure databases

ProteinModelPortaliA6VXA6
SMRiA6VXA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A6VXA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFRRVGII ARLDKPQILD TVKKLMEYLQ EKDIAPVLED QLATMMPGVK
60 70 80 90 100
VASSALKELG DHCDMVMVVG GDGSFLGAAR AICNYDIPVL GINRGTLGFL
110 120 130 140 150
TDISPHNLQE ELDPIFRGEY HEEKRFMIEA KIKRQNRPSG EGIALNDLVL
160 170 180 190 200
HPGKSARMIR FDLFIDDQFV MNQKSDGLIV ATPTGSTAYA LSAGGPIMLP
210 220 230 240 250
KLDALVLVPM HPHTLSNRPI VIDANARIRI VVCESNLTYP SVSCDGQLNI
260 270 280 290
TAAPGDEIHI TKKAGGIRLI HPKNHDFYNV CRDKLGWQSS YRP
Length:293
Mass (Da):32,354
Last modified:August 21, 2007 - v1
Checksum:i9B342181BDFD5704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA Translation: ABR71085.1
RefSeqiWP_012069864.1, NC_009654.1

Genome annotation databases

EnsemblBacteriaiABR71085; ABR71085; Mmwyl1_2163
KEGGimmw:Mmwyl1_2163

Similar proteinsi

Entry informationi

Entry nameiNADK_MARMS
AccessioniPrimary (citable) accession number: A6VXA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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