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Protein

GTP cyclohydrolase-2

Gene

ribA

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotation

Catalytic activityi

GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. GTP cyclohydrolase-2 (ribA)
  2. Riboflavin biosynthesis protein RibD (Mmwyl1_4050)
  3. Riboflavin biosynthesis protein RibD (Mmwyl1_4050)
  4. no protein annotated in this organism
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Zinc; catalyticUniRule annotation
Metal bindingi71 – 711Zinc; catalyticUniRule annotation
Metal bindingi73 – 731Zinc; catalyticUniRule annotation
Binding sitei76 – 761GTPUniRule annotation
Binding sitei119 – 1191GTPUniRule annotation
Active sitei131 – 1311Proton acceptorUniRule annotation
Active sitei133 – 1331NucleophileUniRule annotation
Binding sitei154 – 1541GTPUniRule annotation
Binding sitei159 – 1591GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 595GTPUniRule annotation
Nucleotide bindingi97 – 993GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMSP400668:GHKD-2049-MONOMER.
UniPathwayiUPA00275; UER00400.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase-2UniRule annotation (EC:3.5.4.25UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IIUniRule annotation
Gene namesi
Name:ribAUniRule annotation
Ordered Locus Names:Mmwyl1_2026
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesMarinomonas
Proteomesi
  • UP000001113 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202GTP cyclohydrolase-2PRO_1000077257Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_2026.

Structurei

3D structure databases

ProteinModelPortaliA6VWW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase II family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T1C. Bacteria.
COG0807. LUCA.
HOGENOMiHOG000115442.
KOiK01497.
OMAiTPLVRMH.
OrthoDBiPOG091H008U.

Family and domain databases

CDDicd00641. GTP_cyclohydro2. 1 hit.
HAMAPiMF_00179. RibA. 1 hit.
InterProiIPR032677. GTP_cyclohydro_II.
IPR000926. RibA.
[Graphical view]
PfamiPF00925. GTP_cyclohydro2. 1 hit.
[Graphical view]
SUPFAMiSSF142695. SSF142695. 1 hit.
TIGRFAMsiTIGR00505. ribA. 1 hit.

Sequencei

Sequence statusi: Complete.

A6VWW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLTIKRRV MIPVRAGDVM AEFISFNGDD SGKEHIGIFF EGTKAKADNS
60 70 80 90 100
IPLVRLHSEC LTGDVFGSGR CDCGEQLDEA IDRINEEGGY ILYLRQEGRG
110 120 130 140 150
IGLYAKLEAY ALQDQGYDTY QANEMLHLPD DGRDFGIAAE MLQALGVSKV
160 170 180 190 200
RLLTNNPDKA QQLIEHGIDV AELVPTKVHV NQHNRSYLET KAKRKQHTLK

FD
Length:202
Mass (Da):22,582
Last modified:August 21, 2007 - v1
Checksum:iEAE82A3B80381F81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR70948.1.
RefSeqiWP_012069727.1. NC_009654.1.

Genome annotation databases

EnsemblBacteriaiABR70948; ABR70948; Mmwyl1_2026.
KEGGimmw:Mmwyl1_2026.
PATRICi22467421. VBIMarSp124341_2098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA. Translation: ABR70948.1.
RefSeqiWP_012069727.1. NC_009654.1.

3D structure databases

ProteinModelPortaliA6VWW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi400668.Mmwyl1_2026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR70948; ABR70948; Mmwyl1_2026.
KEGGimmw:Mmwyl1_2026.
PATRICi22467421. VBIMarSp124341_2098.

Phylogenomic databases

eggNOGiENOG4107T1C. Bacteria.
COG0807. LUCA.
HOGENOMiHOG000115442.
KOiK01497.
OMAiTPLVRMH.
OrthoDBiPOG091H008U.

Enzyme and pathway databases

UniPathwayiUPA00275; UER00400.
BioCyciMSP400668:GHKD-2049-MONOMER.

Family and domain databases

CDDicd00641. GTP_cyclohydro2. 1 hit.
HAMAPiMF_00179. RibA. 1 hit.
InterProiIPR032677. GTP_cyclohydro_II.
IPR000926. RibA.
[Graphical view]
PfamiPF00925. GTP_cyclohydro2. 1 hit.
[Graphical view]
SUPFAMiSSF142695. SSF142695. 1 hit.
TIGRFAMsiTIGR00505. ribA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRIBA_MARMS
AccessioniPrimary (citable) accession number: A6VWW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.