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Protein

GTP cyclohydrolase-2

Gene

ribA

Organism
Marinomonas sp. (strain MWYL1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotation

Catalytic activityi

GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. GTP cyclohydrolase-2 (ribA)
  2. Riboflavin biosynthesis protein RibD (Mmwyl1_4050)
  3. Riboflavin biosynthesis protein RibD (Mmwyl1_4050)
  4. no protein annotated in this organism
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc; catalyticUniRule annotation1
Metal bindingi71Zinc; catalyticUniRule annotation1
Metal bindingi73Zinc; catalyticUniRule annotation1
Binding sitei76GTPUniRule annotation1
Binding sitei119GTPUniRule annotation1
Active sitei131Proton acceptorUniRule annotation1
Active sitei133NucleophileUniRule annotation1
Binding sitei154GTPUniRule annotation1
Binding sitei159GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi55 – 59GTPUniRule annotation5
Nucleotide bindingi97 – 99GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processRiboflavin biosynthesis
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMSP400668:G1G9E-2081-MONOMER
UniPathwayiUPA00275; UER00400

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase-2UniRule annotation (EC:3.5.4.25UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IIUniRule annotation
Gene namesi
Name:ribAUniRule annotation
Ordered Locus Names:Mmwyl1_2026
OrganismiMarinomonas sp. (strain MWYL1)
Taxonomic identifieri400668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesOceanospirillaceaeMarinomonas
Proteomesi
  • UP000001113 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000772571 – 202GTP cyclohydrolase-2Add BLAST202

Interactioni

Protein-protein interaction databases

STRINGi400668.Mmwyl1_2026

Structurei

3D structure databases

ProteinModelPortaliA6VWW9
SMRiA6VWW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase II family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T1C Bacteria
COG0807 LUCA
HOGENOMiHOG000115442
KOiK01497
OMAiERTGHLI
OrthoDBiPOG091H008U

Family and domain databases

CDDicd00641 GTP_cyclohydro2, 1 hit
Gene3Di3.40.50.10990, 1 hit
HAMAPiMF_00179 RibA, 1 hit
InterProiView protein in InterPro
IPR032677 GTP_cyclohydro_II
IPR000926 RibA
IPR036144 RibA-like_sf
PfamiView protein in Pfam
PF00925 GTP_cyclohydro2, 1 hit
SUPFAMiSSF142695 SSF142695, 1 hit
TIGRFAMsiTIGR00505 ribA, 1 hit

Sequencei

Sequence statusi: Complete.

A6VWW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLTIKRRV MIPVRAGDVM AEFISFNGDD SGKEHIGIFF EGTKAKADNS
60 70 80 90 100
IPLVRLHSEC LTGDVFGSGR CDCGEQLDEA IDRINEEGGY ILYLRQEGRG
110 120 130 140 150
IGLYAKLEAY ALQDQGYDTY QANEMLHLPD DGRDFGIAAE MLQALGVSKV
160 170 180 190 200
RLLTNNPDKA QQLIEHGIDV AELVPTKVHV NQHNRSYLET KAKRKQHTLK

FD
Length:202
Mass (Da):22,582
Last modified:August 21, 2007 - v1
Checksum:iEAE82A3B80381F81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000749 Genomic DNA Translation: ABR70948.1
RefSeqiWP_012069727.1, NC_009654.1

Genome annotation databases

EnsemblBacteriaiABR70948; ABR70948; Mmwyl1_2026
KEGGimmw:Mmwyl1_2026

Similar proteinsi

Entry informationi

Entry nameiRIBA_MARMS
AccessioniPrimary (citable) accession number: A6VWW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health