Reviewed, UniProtKB/Swiss-Prot A6VW16 (STHA_MARMS)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Ordered Locus Names:	Mmwyl1_1719

Organism

Marinomonas sp. (strain MWYL1) [Complete proteome] [HAMAP]

Taxonomic identifier

400668 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Marinomonas

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247		PRO_1000078411
Regions
	Nucleotide binding	35 – 44	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6VW16-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: BB6EABF4B9DC4B93	FASTA	464	50,726
	10 20 30 40 50 60 MTTRHYDVVV LGTGPAGEGA AMSAAKAGKR VAVIEASSQV GGSCTHLGTI PSKALRHAVK 70 80 90 100 110 120 EIIAFNTNPM FRDIGEPRWF SFPKVLDRAN RVIDKQVMGR TEYYARNRID IYFGRGKFKD 130 140 150 160 170 180 ANTIEVNTYE KGPELLEAKK VVIATGSRPY RPANIDFSHP RIYCSDTILS LSHTPRSLII 190 200 210 220 230 240 YGAGVIGCEY ASIFCGLGVR VELINPAKKL LSFLDDEITD ALSYHLRDGG VLIRHNETYD 250 260 270 280 290 300 SVETTERGVV MHMASGKKLR ADALLFCNGR SGNTDNLGLE SINLEVNSRG QLAVNDTYQT 310 320 330 340 350 360 QVENVYAAGD VIGWPSLASA AYDQGRAAAA NMFGAPGGEF ISEVPTGIYT IPEISSVGKT 370 380 390 400 410 420 EAELTAEKVP YEVGRAFFKN TARAQITGEA VGMLKILFHR ESLELLGIHC FGDQASEIVH 430 440 450 460 IGQAIMKQPG KQNTLKYFLN TTFNYPTMAE AYRVAALNGF NRVF

References

[1]

"Complete sequence of Marinomonas sp. MWYL1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Johnston A.W.B., Todd J.D., Rogers R., Wexler M., Bond P.L., Li Y., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000749 Genomic DNA. Translation: ABR70645.1.
RefSeq	YP_001340580.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VW16.
Genome annotation databases
GeneID	5366770.
GenomeReviews	Gene locus Mmwyl1_1719 in contig CP000749_GR.
KEGG	mmw:Mmwyl1_1719.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GEGNTIE.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00945. HGRDTASE.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STHA_MARMS

Accession

Primary (citable) accession number: A6VW16

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)