Reviewed, UniProtKB/Swiss-Prot A6VQW2 (GCP_ACTSZ)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	Asuc_2013

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_1000073521
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	A6VQW2-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 4827E2F85C316018	FASTA	345	36,721
	10 20 30 40 50 60 MKVLGIETSC DETGVAIYDS EQGLIANQLY TQIALHADYG GVVPELASRD HIRKTAPLIR 70 80 90 100 110 120 AALKEADLTA EDIDGIAYTA GPGLVGALLV GATIARSLAF AWNVPAVSVH HMEGHLLAPM 130 140 150 160 170 180 LESPQNRPHF PFVALLVSGG HTQLVRVDGV GKYELLGESI DDAAGEAFDK TAKLLGLDYP 190 200 210 220 230 240 GGAALSRLAE KGSAGRFTFP KPMTDRPGLD FSFSGLKTAA ANTIRQTIKQ KGDLTEQTKA 250 260 270 280 290 300 DIAHAFQTAV VETLAIKCKR ALQQTGYNTL VIAGGVSANK QLRHRLAQLM HALGGKVFYP 310 320 330 340 SPQFCTDNGA MIAYVGHLRL QAGESSGLEV DVKPRWVMTE LPALA

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR75359.1.
RefSeq	YP_001345294.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VQW2.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	5348664.
GenomeReviews	Gene locus Asuc_2013 in contig CP000746_GR.
KEGG	asu:Asuc_2013.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CKRALKQ.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ACTSZ

Accession

Primary (citable) accession number: A6VQW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)