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A6VQN6 (MRAY_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:Asuc_1935
OrganismActinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]
Taxonomic identifier339671 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000071044

Regions

Transmembrane26 – 4621Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane338 – 35821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A6VQN6 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 55F21AF461E15140

FASTA36040,400
        10         20         30         40         50         60 
MLVWLASFLE QYFSSFHVIS YLTVRAVLSL LTALLLSLWI GPKMILRLQI FKFGQEVRND 

        70         80         90        100        110        120 
GPESHFQKRG TPTMGGIMIL ATITASSLLW GDLSNPYIWC SLFVLLGYGA IGFVDDYRKI 

       130        140        150        160        170        180 
KYKNTDGLIA RWKYFWLSVV AFIAVFTMYM IGKDTDATRL VVPFFKDIMP QLGLFYIVLA 

       190        200        210        220        230        240 
YFVIVGTSNA VNLTDGLDGL AIMPTVFVAG AFAIIAWATG NVEISKYLYI PYVSYTSELV 

       250        260        270        280        290        300 
IFCTAIVGAG LGFLWFNTYP AQVFMGDVGS LALGGALGVI AVLVRQEFLL VIMGGVFVME 

       310        320        330        340        350        360 
TVSVILQVGS YKLRKKRIFR MAPIHHHYEL KGWPEPRVII RFWIISLMLV LLGLVTLKLR

« Hide

References

[1]"Complete sequence of Actinobacillus succinogenes 130Z."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000746 Genomic DNA. Translation: ABR75283.1.
RefSeqYP_001345218.1. NC_009655.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA6VQN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5348183.
GenomeReviewsGene locus Asuc_1935 in contig CP000746_GR.
KEGGasu:Asuc_1935.
PATRIC20762328. VBIActSuc117883_2029.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACTSZ
AccessionPrimary (citable) accession number: A6VQN6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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