Reviewed, UniProtKB/Swiss-Prot A6VQN2 (MURC_ACTSZ)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	Asuc_1931

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP MF_00046
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm Probable HAMAP MF_00046.
Sequence similarities	Belongs to the murCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_1000074728
Regions
	Nucleotide binding	125 – 131	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A6VQN2-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: F9252ECBE9121C9F	FASTA	476	52,030
	10 20 30 40 50 60 MKKRQDKIRQ MVPSMRRVHQ IHFVGIGGAG MGGIAEVLLN EGYDITGSDI AENAVTGRLS 70 80 90 100 110 120 SLGGKIFIGH AATNVENASV VVVSSAIKPD NVEVVAAHEK RIPVIQRAQM LAELMRFRHG 130 140 150 160 170 180 IAIAGTHGKT TTTAMISMIY TQAGLDPTFV NGGLVKSAGT NAYLGASRYL IAEADESDAS 190 200 210 220 230 240 FLHLQPMVSV VTNIEPDHMD TYHGDFDEMK RTYVNFLHNL PFYGLAVMCA DDAVLMELVP 250 260 270 280 290 300 QVGRQVITYG FSEKADYRIE NYEQTGFQGH YDVITPAGER IHILLNVPGK HNALNATAAL 310 320 330 340 350 360 VVAKEEGIGN DAILAALADF QGAGRRFDQL GEFIRPNGKV MLVDDYGHHP TEVGVTIQAA 370 380 390 400 410 420 RSGWENRRVV MVFQPHRYSR TRDLFDDFVR VLSQVDVLIL LDVYPAGEQP IAGADSRSLA 430 440 450 460 470 RSIRNLGKVD PIFVADHGQL PEVVDQIIQD GDLILAQGAG NVSRLSRNLV EHWTKA

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000746 Genomic DNA. Translation: ABR75279.1.
RefSeq	YP_001345214.1.
3D structure databases
SMR	A6VQN2. Positions 15-473.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VQN2.
Genome annotation databases
GeneID	5348934.
GenomeReviews	Gene locus Asuc_1931 in contig CP000746_GR.
KEGG	asu:Asuc_1931.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0773.
HOGENOM	HBG476594.
OMA	YQPHRYS.
Family and domain databases
HAMAP	MF_00046. MurC. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_ACTSZ

Accession

Primary (citable) accession number: A6VQN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	February 9, 2010
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)