A6VQI3 (A6VQI3_ACTSZ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UvrABC system protein A HAMAP-Rule MF_00205
Short name=UvrA protein HAMAP-Rule MF_00205

Alternative name(s):
Excinuclease ABC subunit A HAMAP-Rule MF_00205

Gene names

Name:	uvrA HAMAP-Rule MF_00205
Ordered Locus Names:	Asuc_1879

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP] EMBL ABR75230.1

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus › Actinobacillus succinogenes

Protein attributes

Sequence length	942 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity. SAAS SAAS004602 HAMAP-Rule MF_00205
Subunit structure	Forms a heterotetramer with UvrB during the search for lesions By similarity. SAAS SAAS004602 HAMAP-Rule MF_00205
Subcellular location	Cytoplasm By similarity SAAS SAAS004602 HAMAP-Rule MF_00205.
Sequence similarities	Belongs to the ABC transporter superfamily. UvrA family. HAMAP-Rule MF_00205 Contains 2 ABC transporter domains. HAMAP-Rule MF_00205

Ontologies

Keywords
Biological process	DNA damage DNA excision SAAS SAAS004602 HAMAP-Rule MF_00205 DNA repair SOS response SAAS SAAS004602 HAMAP-Rule MF_00205 Transport HAMAP-Rule MF_00205
Cellular component	Cell inner membrane HAMAP-Rule MF_00205 Cell membrane Cytoplasm SAAS SAAS004602 HAMAP-Rule MF_00205 Membrane
Domain	Repeat SAAS SAAS004602 HAMAP-Rule MF_00205 Zinc-finger SAAS SAAS004602 HAMAP-Rule MF_00205
Ligand	ATP-binding SAAS SAAS004602 HAMAP-Rule MF_00205 DNA-binding SAAS SAAS004602 HAMAP-Rule MF_00205 Metal-binding Nucleotide-binding Zinc
Molecular function	Excision nuclease SAAS SAAS004602 HAMAP-Rule MF_00205
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC SOS response Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: HAMAP cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP ATPase activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Domain	363 – 593	231	ABC transporter 1 By similarity HAMAP-Rule MF_00205
	Domain	607 – 937	331	ABC transporter 2 By similarity HAMAP-Rule MF_00205
	Nucleotide binding	31 – 38	8	ATP By similarity HAMAP-Rule MF_00205
	Zinc finger	253 – 280	28	C4-type By similarity HAMAP-Rule MF_00205
	Nucleotide binding	640 – 647	8	ATP By similarity HAMAP-Rule MF_00205
	Zinc finger	740 – 766	27	C4-type By similarity HAMAP-Rule MF_00205

Sequences

	Sequence		Length	Mass (Da)
	A6VQI3 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: D4A03109D19486E1	FASTA	942	104,080
	10 20 30 40 50 60 MDQIDIRGAR THNLKNINLT IPRDKLIVIT GLSGSGKSSL AFDTLYAEGQ RRYVESLSAY 70 80 90 100 110 120 ARQFLSLMEK PDVDSIEGLS PAISIEQKST SHNPRSTVGT VTEIHDYLRL LFARVGEPRC 130 140 150 160 170 180 PHHNVPLAAQ TISQMVDKVL SLPEESRMML LAPVVKARKG EHVKILEQIA AQGYIRARID 190 200 210 220 230 240 GEICDLSDPP KLELQKKHSI EVVVDRFKVR SDLATRLAES FETTLELSGG TAVVASMDDS 250 260 270 280 290 300 KAEELVFSAN FACPHCGYSV PELEPRLFSF NNPAGACPTC DGLGVEQYFD EARVVQHPGI 310 320 330 340 350 360 SLASGAVKGW DRRNFYYYQM MKSLSSHYHF DLEAPFESLP KKIRDIVLYG SGNEEIEFVY 370 380 390 400 410 420 LNDRGDSVVR RHPFEGILNN MTRRYKETES MSVREELAKN ISTRPCKDCC GSRLRPEARH 430 440 450 460 470 480 VYIGQTNLPD IAEMSIGDAL AFFEKMALAG QKAQIAEKIL KEIKERLSFL VNVGLNYLSL 490 500 510 520 530 540 SRSAETLSGG EAQRIRLASQ IGAGLVGVMY VLDEPSIGLH QRDNERLLNT LIHLRNLGNT 550 560 570 580 590 600 VIVVEHDEDA IRAADHIIDI GPGAGVHGGE IIAQGNAEQI MANPNSVTGQ FLSGKEKIEI 610 620 630 640 650 660 PSKRTALNKK KILRLNGATG NNLKSVNLEI PVGLFTCITG VSGSGKSTLI NDTLFPLAQN 670 680 690 700 710 720 ALNRADNIDF APYKSIEGLE HFDKVINIDQ SPIGRTPRSN PATYTGLFTP IRELFAGVPE 730 740 750 760 770 780 SRARGYNPGR FSFNVRGGRC EACQGDGVIK VEMHFLPDVY VPCDQCKGKR YNRETLEIRY 790 800 810 820 830 840 KGKTIHQVLD MTVEEAREFF DAIPAIARKL QTLMDVGLSY IRLGQSSTTL SGGEAQRVKL 850 860 870 880 890 900 ATELSKRDTG KTLYVLDEPT TGLHFADIKQ LLEVLHRLRD QGNTIVVIEH NLDVIKTADW 910 920 930 940 IVDLGPEGGN GGGEIIATGT PEQVAKDPHS HTARFLNPML TQ

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000746 Genomic DNA. Translation: ABR75230.1.
RefSeq	YP_001345165.1. NC_009655.1.
3D structure databases
ProteinModelPortal	A6VQI3.
SMR	A6VQI3. Positions 1-941.
ModBase	Search...
Protein-protein interaction databases
STRING	339671.Asuc_1879.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR75230; ABR75230; Asuc_1879.
GeneID	5349370.
KEGG	asu:Asuc_1879.
PATRIC	20762210. VBIActSuc117883_1970.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0178.
HOGENOM	HOG000050448.
KO	K03701.
OMA	GAIKGWD.
ProtClustDB	PRK00349.
Enzyme and pathway databases
BioCyc	ASUC339671:GHDX-1961-MONOMER.
Family and domain databases
Gene3D	3.30.1490.20. 2 hits.
HAMAP	MF_00205. UvrA.
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR013815. ATP_grasp_subdomain_1. IPR004602. UvrA. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
TIGRFAMs	TIGR00630. uvra. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A6VQI3_ACTSZ

Accession

Primary (citable) accession number: A6VQI3

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)