Reviewed, UniProtKB/Swiss-Prot A6VQA9 (SYD_ACTSZ)

Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase
      Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	Asuc_1805

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	589 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 589	589	Aspartyl-tRNA synthetase HAMAP MF_00044		PRO_1000071082

Sequences

	Sequence		Length	Mass (Da)
	A6VQA9-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: B836012E164F3E56	FASTA	589	66,297
	10 20 30 40 50 60 MMRSHYCGAL NRGNIGQEVT LSGWVHRRRD LGGLIFIDMR DREGIVQVCF DPKYQEALTA 70 80 90 100 110 120 AADLRNEFCI QIKGEVTARP GNQINKNMAT GEVEVLAKAL SVYNASDVLP LDFNQNNTEE 130 140 150 160 170 180 QRLKYRYLDL RRPEMAQRLK TRAKITSFVR RFMDDHGFLD IETPMLTKAT PEGARDYLVP 190 200 210 220 230 240 SRVHKGKFYA LPQSPQLFKQ LLMMSGFDRY YQIVKCFRDE DLRADRQPEF TQIDVETSFL 250 260 270 280 290 300 TAPEVRAIME NMIRGLWLNI LGADLGKFPI MTWNEAMTRF GSDKPDLRNP LEIADVADIV 310 320 330 340 350 360 KDVDFKVFAD PANDANGRVS VIRVPNGASI TRKQIDEYTQ FVGIYGAKGL AWLKVNDVNA 370 380 390 400 410 420 GLEGVQSPIA KFLSEEKIKA IFDRTSAQTG DILFFGADKW QIATDAMGAL RLKLGRDLGL 430 440 450 460 470 480 TRLDEWQPLW VIDFPMFECD EEGNLAAMHH PFTSPKDFSP EQLEADPTAA VANAYDMVIN 490 500 510 520 530 540 GYEVGGGSVR IFDPKMQQTV FRILGIDEQQ QREKFGFLLD ALKFGTPPHA GLAFGLDRLT 550 560 570 580 MLLTGTDNIR DVIAFPKTTA AACLMTEAPS FANQQALEEL AITVVTKEE

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR75156.1.
RefSeq	YP_001345091.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VQA9.
Genome annotation databases
GeneID	5349358.
GenomeReviews	Gene locus Asuc_1805 in contig CP000746_GR.
KEGG	asu:Asuc_1805.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VDRRRDH.
Family and domain databases
HAMAP	MF_00044. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR002312. Asp-tRNA-synth_IIb. IPR020564. Asp-tRNA-synth_IIb_bac-type. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR004115. GAD_dom. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_ACTSZ

Accession

Primary (citable) accession number: A6VQA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)