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Protein

UvrABC system protein C

Gene

uvrC

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:Asuc_1724
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001114 Componenti: Chromosome

Subcellular locationi

A6VQ29:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000777471 – 608UvrABC system protein CAdd BLAST608

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi339671.Asuc_1724.

Structurei

3D structure databases

ProteinModelPortaliA6VQ29.
SMRiA6VQ29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 91GIY-YIGUniRule annotationAdd BLAST79
Domaini201 – 236UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII. Bacteria.
COG0322. LUCA.
HOGENOMiHOG000279961.
KOiK03703.
OMAiLFPIRQC.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiView protein in InterPro
IPR000305. GIY-YIG_endonuc.
IPR035901. GIY-YIG_endonuc_sf.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
PfamiView protein in Pfam
PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
SMARTiView protein in SMART
SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiView protein in PROSITE
PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.

Sequencei

Sequence statusi: Complete.

A6VQ29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDSKAFLKN VPHDPGVYRM FDKTDTVIYV GKAKDLKKRL SSYFRPNLSS
60 70 80 90 100
KKTEALVASI TRIETTITTS ETEALLLEHN YIKTFQPRYN VLLRDDKSYP
110 120 130 140 150
YILLTKERHP RIAAYRGAKK IQGEYFGPYP HAGAVRETLS LLQKLFPIRQ
160 170 180 190 200
CENSVYKNRS RPCLQYQIGR CCAPCVAGYV TDEEYQAQVE YARLFLQGKD
210 220 230 240 250
QQVLDHLIAK METASRALDF ENAARFRDQI QAVRAVIEKQ FVSNDRLDDM
260 270 280 290 300
DIISIAYRHG VACVQVLFIR QGKVLGNRSY FPKVPANTDL SELTATFVGQ
310 320 330 340 350
FYLQAHQGRT VPNSIVVDHK LEAKEEIEQL LSEQAGRKVS IQDNAKGSKS
360 370 380 390 400
KYLSLAQMNA KAALTLKLKE STLISERYRA LRELLDMDKI NRMECFDISH
410 420 430 440 450
TMGEQTIASC VVFNDAGPFK SEYRRFNIEG ITGGDDYAAM EQALKKRYDR
460 470 480 490 500
DLTPEKIPDI IFIDGGKGQL NRALKAFGEL NVKWDKNRPH LIGIAKGVDR
510 520 530 540 550
RAGQETLILS KTGREVNLDP DNLALHLIQH IRDESHNHAI SGHRKKRQKA
560 570 580 590 600
FTQSGLETIE GVGPKRRQAL LKYLGGMQGV KNATLEEIAS VPGISRALAE

IIFETLKH
Length:608
Mass (Da):68,933
Last modified:August 21, 2007 - v1
Checksum:iDAC7C657B4438B8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000746 Genomic DNA. Translation: ABR75076.1.
RefSeqiWP_012073453.1. NC_009655.1.

Genome annotation databases

EnsemblBacteriaiABR75076; ABR75076; Asuc_1724.
KEGGiasu:Asuc_1724.

Similar proteinsi

Entry informationi

Entry nameiUVRC_ACTSZ
AccessioniPrimary (citable) accession number: A6VQ29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families