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A6VPG7

- THIM_ACTSZ

UniProt

A6VPG7 - THIM_ACTSZ

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411Substrate; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171ATPUniRule annotation
    Binding sitei165 – 1651ATPUniRule annotation
    Binding sitei192 – 1921Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciASUC339671:GHDX-1576-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:Asuc_1506
    OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
    Taxonomic identifieri339671 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
    ProteomesiUP000001114: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Hydroxyethylthiazole kinasePRO_0000336544Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi339671.Asuc_1506.

    Structurei

    3D structure databases

    ProteinModelPortaliA6VPG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiQTFTANV.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6VPG7-1 [UniParc]FASTAAdd to Basket

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    MQFRYLSLVR QQAPLEHCIT NIVVTNFSAN GLLALGASPF MSAMPQEVTE    50
    IQNFAQALLI NIGTLNQSDV EAMLIAGKAA NRTGVPVVLD PVGAGATLFR 100
    RKIVEQFLAE INFAVIRGNA AEIGFLAGTD WQGKGVDAGT GADSENLSRL 150
    AQSVAQKYRC VVALSGETDF ISDGLKTYQI CNGTRMLPKV TGSGCLLGAV 200
    IAAFLGVSPP QDYFSACTEA CTVYAVAGEL AAQGLSNEYG SFAMNFINQL 250
    GAIHETRLAD KARVLAQHE 269
    Length:269
    Mass (Da):28,511
    Last modified:August 21, 2007 - v1
    Checksum:i662B6FC2F369E9BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000746 Genomic DNA. Translation: ABR74864.1.
    RefSeqiYP_001344799.1. NC_009655.1.

    Genome annotation databases

    EnsemblBacteriaiABR74864; ABR74864; Asuc_1506.
    GeneIDi5348079.
    KEGGiasu:Asuc_1506.
    PATRICi20761394. VBIActSuc117883_1571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000746 Genomic DNA. Translation: ABR74864.1 .
    RefSeqi YP_001344799.1. NC_009655.1.

    3D structure databases

    ProteinModelPortali A6VPG7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 339671.Asuc_1506.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR74864 ; ABR74864 ; Asuc_1506 .
    GeneIDi 5348079.
    KEGGi asu:Asuc_1506.
    PATRICi 20761394. VBIActSuc117883_1571.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi QTFTANV.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci ASUC339671:GHDX-1576-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production."
      McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A., Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L., Burkhart K.B., Harkins V., Vieille C.
      BMC Genomics 11:680-680(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 55618 / 130Z.

    Entry informationi

    Entry nameiTHIM_ACTSZ
    AccessioniPrimary (citable) accession number: A6VPG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3