Reviewed, UniProtKB/Swiss-Prot A6VP88 (ALR_ACTSZ)

Names and origin

Protein names

Recommended name:
    Alanine racemase
    EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	Asuc_1426

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Alanine racemase HAMAP MF_01201		PRO_1000073092
Sites
	Active site	34	1	Proton acceptor; specific for D-alanine By similarity
	Active site	254	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	34	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6VP88-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: C24E1A6F2BB40347	FASTA	358	39,357
	10 20 30 40 50 60 MKPATAKISS LALKHNLELI HQKAPDSKMI AIVKANAYGH GVEFVASTVE EQVDGFGVAR 70 80 90 100 110 120 IEEALTLRSK GIIKPILLLE GFFSAKDLPV IAVNNIQTVV HNREQLEALK QTKLPNPIKV 130 140 150 160 170 180 WLKIDTGMHR LGVALDEVED YVEELKKCAN VEPLIGYVSH FSRADELDSD YTRIQLNRFL 190 200 210 220 230 240 QATEDKGGPR CIAASGGILF WPDSHLEWIR PGIIMYGVSP TDTPSSEFGL IPVMTLTSSL 250 260 270 280 290 300 IAVRRHKAGE PVGYGGTWIS KKDTKIGVIA IGYGDGYPRN IPSGTPVYIN GRIVPIVGRV 310 320 330 340 350 SMDMITVDLG EDCTDKVGDE VILWGKELPI ETVAKHMGIL SYELMTKLTP RVLTEYAD

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR74785.1.
RefSeq	YP_001344720.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VP88.
Genome annotation databases
GeneID	5349079.
GenomeReviews	Gene locus Asuc_1426 in contig CP000746_GR.
KEGG	asu:Asuc_1426.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EGTPVWV.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_ACTSZ

Accession

Primary (citable) accession number: A6VP88

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)