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Protein

Class B acid phosphatase

Gene

aphA

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity).By similarity

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68NucleophileBy similarity1
Metal bindingi68MagnesiumBy similarity1
Active sitei70Proton donorBy similarity1
Metal bindingi70Magnesium; via carbonyl oxygenBy similarity1
Binding sitei183SubstrateBy similarity1
Metal bindingi198MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciASUC339671:G1G9D-1484-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Class B acid phosphataseBy similarity (EC:3.1.3.2By similarityImported)
Short name:
CBAPBy similarity
Gene namesi
Name:aphABy similarity
Ordered Locus Names:Asuc_1410
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001114 Componenti: Chromosome

Subcellular locationi

  • Periplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500025889323 – 243Class B acid phosphataseSequence analysisAdd BLAST221

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi339671.Asuc_1410

Structurei

3D structure databases

ProteinModelPortaliA6VP72
SMRiA6VP72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni136 – 137Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the class B bacterial acid phosphatase family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105F0S Bacteria
COG3700 LUCA
HOGENOMiHOG000270623
KOiK03788
OMAiPEFWEKM
OrthoDBiPOG091H06BK

Family and domain databases

CDDicd07499 HAD_CBAP, 1 hit
Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR005519 Acid_phosphat_B-like
IPR036412 HAD-like_sf
IPR010025 HAD-SF_ppase_IIIB_AphA
IPR023214 HAD_sf
PfamiView protein in Pfam
PF03767 Acid_phosphat_B, 1 hit
PIRSFiPIRSF017818 Acid_Ptase_B, 1 hit
SFLDiSFLDG01127 C1.3:_Acid_Phosphatase_Like, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01672 AphA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6VP72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLIKSSVFM FSMLTIAVSA NAKGPKVSYD HAGITAIDHK NEAQVKWVSA
60 70 80 90 100
ESIQKELKGK PPITVSFDID DTVLVSSQCF YYGKQTFSPD SLDYLHNQAY
110 120 130 140 150
WDFVADGCDN YSIPKESAKK LIDMHQARGD QVIFITGRTP HRLHKAGQMD
160 170 180 190 200
QLARILERAF HIKNMKPINY THDKPIAPYK YDKTRFMVEN RVSIHYGDSN
210 220 230 240
DDILAAREAG IRGIRVIRSA TSTNRPLPLN GGYGEEVVED SSY
Length:243
Mass (Da):27,365
Last modified:August 21, 2007 - v1
Checksum:i32E3AAF37288EB6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000746 Genomic DNA Translation: ABR74769.1
RefSeqiWP_012073146.1, NC_009655.1

Genome annotation databases

EnsemblBacteriaiABR74769; ABR74769; Asuc_1410
KEGGiasu:Asuc_1410

Similar proteinsi

Entry informationi

Entry nameiAPHA_ACTSZ
AccessioniPrimary (citable) accession number: A6VP72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: August 21, 2007
Last modified: February 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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