A6VP11 (SYQ_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamine--tRNA ligase
EC=6.1.1.18

Alternative name(s):
Glutaminyl-tRNA synthetase
Short name=GlnRS

Gene names

Name:	glnS
Ordered Locus Names:	Asuc_1348

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus › Actinobacillus succinogenes

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). HAMAP-Rule MF_00126
Subunit structure	Monomer By similarity. HAMAP-Rule MF_00126
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00126.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glutaminyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro glutamyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP glutamine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Glutamine--tRNA ligase HAMAP-Rule MF_00126		PRO_1000095475
Regions
	Motif	44 – 54	11	"HIGH" region HAMAP-Rule MF_00126
	Motif	279 – 283	5	"KMSKS" region HAMAP-Rule MF_00126
Sites
	Binding site	282	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6VP11 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: E8377817F028EE04	FASTA	559	64,366
	10 20 30 40 50 60 MATANIELQS AAEHEAHPTN FIRQIIDEDL ATGKHHNVYT RFPPEPNGYL HIGHAKSICL 70 80 90 100 110 120 NFGIAQDYHG KCNLRFDDTN PVKEDVEYVD SIKQDVEWLG FNWEGEPRYA SDYFDQLYGY 130 140 150 160 170 180 AVELIEKGLA YVDELSPEEM REYRGTLTEA GKNSPYRERS VAENLALFEK MRNGEFAEGK 190 200 210 220 230 240 ACLRAKIDMA SPFMVMRDPV IYRVKFASHH QTGDKWCIYP MYDFTHCISD AIERITHSLC 250 260 270 280 290 300 TLEFQDNRRL YDWVLEHISI ERPLPHQYEF SRLNLEGTLT SKRKLLKLVE EGAVDGWDDP 310 320 330 340 350 360 RMPTISGLRR RGYTPASLRE FCRRIGVTKQ DNVVEFSALE SCIRDDLNIN APRAMAVINP 370 380 390 400 410 420 LKVIIENFET PETLTMPNHP NREEMGTRQV QLTKELYIDQ ADFREEANKQ YKRLVLGKEV 430 440 450 460 470 480 RLRNAYIIKA ERVEKDAEGN IVCVYCSYDP ETLGKNPSDG RKVKGVIQWV SATDCLPAEF 490 500 510 520 530 540 RQYSRLFTMP NPGSEEDIIA AINPQSLVVR QGFVERSVAN ALSEKAYQFE REGYYCADSK 550 DSRPDHLVFN LTVSLKEGF

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000746 Genomic DNA. Translation: ABR74708.1.
RefSeq	YP_001344643.1. NC_009655.1.
3D structure databases
ProteinModelPortal	A6VP11.
SMR	A6VP11. Positions 19-557.
ModBase	Search...
Protein-protein interaction databases
STRING	339671.Asuc_1348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR74708; ABR74708; Asuc_1348.
GeneID	5348033.
KEGG	asu:Asuc_1348.
PATRIC	20761066. VBIActSuc117883_1410.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0008.
HOGENOM	HOG000259232.
KO	K01886.
OMA	RMPTIAG.
ProtClustDB	PRK05347.
Enzyme and pathway databases
BioCyc	ASUC339671:GHDX-1415-MONOMER.
Family and domain databases
Gene3D	1.10.1160.10. 1 hit. 2.40.240.10. 2 hits. 3.40.50.620. 2 hits.
HAMAP	MF_00126. Gln_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR004514. Gln-tRNA-synth_Ib. IPR022861. Gln_tRNA_ligase_bac. IPR000924. Glu/Gln-tRNA-synth_Ib. IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd. IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl. IPR011035. Ribosomal_L25/Gln-tRNA_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR10119. PTHR10119. 1 hit.
Pfam	PF00749. tRNA-synt_1c. 1 hit. PF03950. tRNA-synt_1c_C. 1 hit. [Graphical view]
PRINTS	PR00987. TRNASYNTHGLU.
SUPFAM	SSF50715. Ribosomal_L25rel. 1 hit.
TIGRFAMs	TIGR00440. glnS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYQ_ACTSZ

Accession

Primary (citable) accession number: A6VP11

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	August 21, 2007
Last modified:	May 29, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program