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Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77L-glutamineUniRule annotation1
Binding sitei222L-glutamineUniRule annotation1
Binding sitei241ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 47ATPUniRule annotation3
Nucleotide bindingi51 – 57ATPUniRule annotation7
Nucleotide bindingi272 – 273ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligaseUniRule annotation (EC:6.1.1.18UniRule annotation)
Alternative name(s):
Glutaminyl-tRNA synthetaseUniRule annotation
Short name:
GlnRSUniRule annotation
Gene namesi
Name:glnSUniRule annotation
Ordered Locus Names:Asuc_1348
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001114 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000954751 – 559Glutamine--tRNA ligaseAdd BLAST559

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi339671.Asuc_1348.

Structurei

3D structure databases

ProteinModelPortaliA6VP11.
SMRiA6VP11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 54"HIGH" regionUniRule annotationAdd BLAST11
Motifi279 – 283"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CX6. Bacteria.
COG0008. LUCA.
HOGENOMiHOG000259232.
KOiK01886.
OMAiVTHSICT.
OrthoDBiPOG091H00G9.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 3 hits.
HAMAPiMF_00126. Gln_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A6VP11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATANIELQS AAEHEAHPTN FIRQIIDEDL ATGKHHNVYT RFPPEPNGYL
60 70 80 90 100
HIGHAKSICL NFGIAQDYHG KCNLRFDDTN PVKEDVEYVD SIKQDVEWLG
110 120 130 140 150
FNWEGEPRYA SDYFDQLYGY AVELIEKGLA YVDELSPEEM REYRGTLTEA
160 170 180 190 200
GKNSPYRERS VAENLALFEK MRNGEFAEGK ACLRAKIDMA SPFMVMRDPV
210 220 230 240 250
IYRVKFASHH QTGDKWCIYP MYDFTHCISD AIERITHSLC TLEFQDNRRL
260 270 280 290 300
YDWVLEHISI ERPLPHQYEF SRLNLEGTLT SKRKLLKLVE EGAVDGWDDP
310 320 330 340 350
RMPTISGLRR RGYTPASLRE FCRRIGVTKQ DNVVEFSALE SCIRDDLNIN
360 370 380 390 400
APRAMAVINP LKVIIENFET PETLTMPNHP NREEMGTRQV QLTKELYIDQ
410 420 430 440 450
ADFREEANKQ YKRLVLGKEV RLRNAYIIKA ERVEKDAEGN IVCVYCSYDP
460 470 480 490 500
ETLGKNPSDG RKVKGVIQWV SATDCLPAEF RQYSRLFTMP NPGSEEDIIA
510 520 530 540 550
AINPQSLVVR QGFVERSVAN ALSEKAYQFE REGYYCADSK DSRPDHLVFN

LTVSLKEGF
Length:559
Mass (Da):64,366
Last modified:August 21, 2007 - v1
Checksum:iE8377817F028EE04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000746 Genomic DNA. Translation: ABR74708.1.
RefSeqiWP_012073085.1. NC_009655.1.

Genome annotation databases

EnsemblBacteriaiABR74708; ABR74708; Asuc_1348.
KEGGiasu:Asuc_1348.

Similar proteinsi

Entry informationi

Entry nameiSYQ_ACTSZ
AccessioniPrimary (citable) accession number: A6VP11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 21, 2007
Last modified: August 30, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families