A6VNV7 (SYN_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Asparagine--tRNA ligase
EC=6.1.1.22

Alternative name(s):
Asparaginyl-tRNA synthetase
Short name=AsnRS

Gene names

Name:	asnS
Ordered Locus Names:	Asuc_1294

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534
Subunit structure	Homodimer By similarity. HAMAP MF_00534
Subcellular location	Cytoplasm HAMAP MF_00534.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW asparagine-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Asparagine--tRNA ligase HAMAP MF_00534		PRO_1000072528

Sequences

	Sequence		Length	Mass (Da)
	A6VNV7 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 235AD331BE433681	FASTA	467	52,634
	10 20 30 40 50 60 MTKIASIADV LQGEIAVGEK VTVRGWVRTR RDSKAGLSFL TVYDGSCFNP IQAIINNDIV 70 80 90 100 110 120 NYESEVLRLT AGCSVIVTGT VVESPAQGQA VELQTETVEV VGWVEDPDTY PMAAKRHSIE 130 140 150 160 170 180 YLREVAHLRP RTNIIGAVAR VRHCLAQAIH RFFHEQGFYW VATPLITASD TEGAGEMFRV 190 200 210 220 230 240 STLDLENLPR TQAGTVDFNQ DFFGKEAFLT VSGQLNGETY ACALSKIYTF GPTFRAENSN 250 260 270 280 290 300 TTRHLAEFWM VEPEIAFATL ADNAKLAEDM LKYVFNAVLT ERRDDLEFFS KHVDKDVITR 310 320 330 340 350 360 LEHFVNSPFA QIDYTDAIDV LVKSGKKFEF PVSWGIDLSS EHERYLAEEH FKSPVVVKNY 370 380 390 400 410 420 PKGIKAFYMR LNDDGKTVAA MDVLAPGIGE IIGGSQREER LDVLDKRMVE MGLKPEDYWW 430 440 450 460 YRDLRKYGTV PHSGFGLGFE RLIVYVTGVQ NIRDVIPFPR SPRNANF

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000746 Genomic DNA. Translation: ABR74654.1.
RefSeq	YP_001344589.1. NC_009655.1.
3D structure databases
ProteinModelPortal	A6VNV7.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VNV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5349647.
GenomeReviews	Gene locus Asuc_1294 in contig CP000746_GR.
KEGG	asu:Asuc_1294.
PATRIC	20760956. VBIActSuc117883_1355.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0017.
HOGENOM	HBG745843.
OMA	AIHRFFH.
ProtClustDB	PRK03932.
Family and domain databases
HAMAP	MF_00534. Asn_tRNA_synth. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K01893.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF6. PTHR22594:SF6. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00457. AsnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYN_ACTSZ

Accession

Primary (citable) accession number: A6VNV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program