A6VNL8 (QUEF_ACTSZ) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 45.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: NADPH-dependent 7-cyano-7-deazaguanine reductase EC=1.7.1.13 Alternative name(s): 7-cyano-7-carbaguanine reductase NADPH-dependent nitrile oxidoreductase PreQ(0) reductase | ||||
| Gene names |
| ||||
| Organism | Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 339671 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus › ![]() |
Protein attributes
| Sequence length | 279 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity. HAMAP-Rule MF_00817 |
| Catalytic activity | 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH. HAMAP-Rule MF_00817 |
| Pathway | tRNA modification; tRNA-queuosine biosynthesis. HAMAP-Rule MF_00817 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Queuosine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | queuosine biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Inferred from electronic annotation. Source: HAMAP preQ1 synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 279 | 279 | NADPH-dependent 7-cyano-7-deazaguanine reductase HAMAP-Rule MF_00817 | PRO_1000072868 | |||
Sequences
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References
| [1] | "Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 55618 / 130Z. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000746 Genomic DNA. Translation: ABR74565.1. |
| RefSeq | YP_001344500.1. NC_009655.1. |
3D structure databases | |
| ProteinModelPortal | A6VNL8. |
| SMR | A6VNL8. Positions 19-279. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 339671.Asuc_1201. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | ABR74565; ABR74565; Asuc_1201. |
| GeneID | 5348416. |
| KEGG | asu:Asuc_1201. |
| PATRIC | 20760796. VBIActSuc117883_1276. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0780. |
| HOGENOM | HOG000273755. |
| KO | K06879. |
| OMA | ERIFCDL. |
| ProtClustDB | PRK11792. |
Enzyme and pathway databases | |
| BioCyc | ASUC339671:GHDX-1283-MONOMER. |
| UniPathway | UPA00392. |
Family and domain databases | |
| HAMAP | MF_00817. QueF_type2. |
| InterPro | IPR016428. CN_OxRdtase_NADPH-dep_YqcD. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. [Graphical view] |
| Pfam | PF01227. GTP_cyclohydroI. 1 hit. [Graphical view] |
| PIRSF | PIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit. |
| TIGRFAMs | TIGR03138. QueF. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | QUEF_ACTSZ | ||||||||
| Accession | Primary (citable) accession number: A6VNL8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
