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A6VND6 (BIOD_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent dethiobiotin synthetase BioD
EC=6.3.3.3
Alternative name(s):
DTB synthetase
Short name=DTBS
Dethiobiotin synthase
Gene names
Name:bioD
Ordered Locus Names:Asuc_1117
OrganismActinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]
Taxonomic identifier339671 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring By similarity. HAMAP MF_00336

Catalytic activity

ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336

Cofactor

Magnesium By similarity. HAMAP MF_00336

Pathway

Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336

Subcellular location

Cytoplasm By similarity HAMAP MF_00336.

Sequence similarities

Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
   Biological processBiotin biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbiotin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

dethiobiotin synthase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242ATP-dependent dethiobiotin synthetase BioD HAMAP MF_00336
PRO_1000072045

Regions

Nucleotide binding184 – 1852ATP By similarity
Nucleotide binding213 – 2153ATP By similarity

Sites

Metal binding161Magnesium 2 By similarity
Metal binding661Magnesium 2 By similarity
Metal binding1241Magnesium 2 By similarity
Binding site411Substrate By similarity
Binding site661ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6VND6 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: CF4AC21760CF62FE

FASTA24226,881
        10         20         30         40         50         60 
MRTFFVTGTD TGVGKTICSR AIIQALQEMD TQIVGFKPIA SGQDEPVYAD SLDDPKNDYG 

        70         80         90        100        110        120 
DEDNRDVLIL QNSTKENVSY RDINSYTFLQ TVPMITAEKG RIKLEKVDRD LARLAATYDV 

       130        140        150        160        170        180 
VAVEGSFGWL SPMNERFTFA DWVVKHNMPV IVAVGIKEGC INHALLTVQS VEKMGLPVLG 

       190        200        210        220        230        240 
WIANRINPGL SHYAEIIDVL SSKIAAPLLG CIPYIHKPET QDVGKFLTNT EQLRHIQTLL 


AK

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References

[1]"Complete sequence of Actinobacillus succinogenes 130Z."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000746 Genomic DNA. Translation: ABR74483.1.
RefSeqYP_001344418.1. NC_009655.1.

3D structure databases

ProteinModelPortalA6VND6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6VND6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5349657.
GenomeReviewsGene locus Asuc_1117 in contig CP000746_GR.
KEGGasu:Asuc_1117.
PATRIC20760608. VBIActSuc117883_1183.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0132.
HOGENOMHBG650065.
OMAINPGLSH.
ProtClustDBPRK00090.

Family and domain databases

HAMAPMF_00336. BioD.
[Tree]
InterProIPR002586. CbiA_P_synth.
IPR004472. DTB_synth_BioD.
[Graphical view]
KOK01935.
PfamPF01656. CbiA. 1 hit.
[Graphical view]
PIRSFPIRSF006755. DTB_synth. 1 hit.
TIGRFAMsTIGR00347. BioD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBIOD_ACTSZ
AccessionPrimary (citable) accession number: A6VND6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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