Reviewed, UniProtKB/Swiss-Prot A6VND6 (BIOD_ACTSZ)

Names and origin

Protein names

Recommended name:
    Dethiobiotin synthetase
    EC=6.3.3.3
Alternative name(s):
    Dethiobiotin synthase
    DTB synthetase
      Short name=DTBS

Gene names

Name:	bioD
Ordered Locus Names:	Asuc_1117

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336
Cofactor	Magnesium By similarity.
Pathway	Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336
Sequence similarities	Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dethiobiotin synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Dethiobiotin synthetase HAMAP MF_00336		PRO_1000072045
Regions
	Nucleotide binding	8 – 16	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6VND6-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: CF4AC21760CF62FE	FASTA	242	26,881
	10 20 30 40 50 60 MRTFFVTGTD TGVGKTICSR AIIQALQEMD TQIVGFKPIA SGQDEPVYAD SLDDPKNDYG 70 80 90 100 110 120 DEDNRDVLIL QNSTKENVSY RDINSYTFLQ TVPMITAEKG RIKLEKVDRD LARLAATYDV 130 140 150 160 170 180 VAVEGSFGWL SPMNERFTFA DWVVKHNMPV IVAVGIKEGC INHALLTVQS VEKMGLPVLG 190 200 210 220 230 240 WIANRINPGL SHYAEIIDVL SSKIAAPLLG CIPYIHKPET QDVGKFLTNT EQLRHIQTLL AK

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR74483.1.
RefSeq	YP_001344418.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VND6.
Genome annotation databases
GeneID	5349657.
GenomeReviews	Gene locus Asuc_1117 in contig CP000746_GR.
KEGG	asu:Asuc_1117.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ETPEGMR.
Family and domain databases
HAMAP	MF_00336. [Tree]
InterPro	IPR004472. BioD_synth. [Graphical view]
PIRSF	PIRSF006755. DTB_synth. 1 hit.
TIGRFAMs	TIGR00347. bioD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIOD_ACTSZ

Accession

Primary (citable) accession number: A6VND6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)