A6VNB3 (SYR_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	Asuc_1094

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus › Actinobacillus succinogenes

Protein attributes

Sequence length	575 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity. HAMAP-Rule MF_00123
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: UniProtKB-HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 575	575	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_1000071392
Regions
	Motif	122 – 132	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	A6VNB3 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 85399351322A9C34	FASTA	575	64,397
	10 20 30 40 50 60 MNIQQLLSEK IRHAMIAAGA QQPAEPAVRQ SGKPQFGDYQ ANGIMGAAKK LGLNPREFAQ 70 80 90 100 110 120 KVLDNLNLDG IAEKLEIAGP GFINIFLSKN WLVCHADEML SAVNFGIKTA KPQTIVVDYS 130 140 150 160 170 180 SPNVAKEMHV GHLRSTIIGD AVVRTLEFLG NHVIRANHVG DWGTQFGMLI AYLEKMENEN 190 200 210 220 230 240 ASAMQLSDLE AFYRAAKEHY DNDEAFAEKA RNYVVKLQSG DEYCRIMWKK LVDITMRHNQ 250 260 270 280 290 300 ENYDRLNVTL TEKDVMGESL YNPMLPEIVA DLKKQGLAVE DDGALVVYLD EFKNKDGDPM 310 320 330 340 350 360 GVIVQKKDGG YLYTTTDIAA AKYRCHKLHA DRVLVFSDSR QSQHMQQAWL ITRKAGYVPD 370 380 390 400 410 420 SFSLEHPFFG MMLGKDGKPF KTRTGGTVKL KDLLDEAVER ADKLIAERNP DLTAEEKAAV 430 440 450 460 470 480 VEAVAIGSVK YSDLSKNRTT DYVFDWDNML TFEGNTAPYM QYAYTRIRSI FARAGIEPNS 490 500 510 520 530 540 LNDDIVLTDD KERVLVIKLL QFEEALNGVA KDGMPHILCQ YLYELAGMFS AFYEACPILN 550 560 570 AERPIKNSRL KLAALAAKTL KQGLDLLGIK TVEKM

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000746 Genomic DNA. Translation: ABR74460.1.
RefSeq	YP_001344395.1. NC_009655.1.
3D structure databases
ProteinModelPortal	A6VNB3.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	339671.Asuc_1094.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR74460; ABR74460; Asuc_1094.
GeneID	5347590.
KEGG	asu:Asuc_1094.
PATRIC	20760562. VBIActSuc117883_1160.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247212.
KO	K01887.
OMA	DGTAVYM.
OrthoDB	EOG6JB13C.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	ASUC339671:GHDX-1157-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF47323. SSF47323. 1 hit. SSF55190. SSF55190. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_ACTSZ

Accession

Primary (citable) accession number: A6VNB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program