argS

Functionⁱ

Catalytic activityⁱ

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functionⁱ

arginine-tRNA ligase activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arginyl-tRNA aminoacylation Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetase, Ligase
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	ASUC339671:G1G9D-1161-MONOMER

BioCycⁱ

ASUC339671:G1G9D-1161-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation) Alternative name(s): Arginyl-tRNA synthetaseUniRule annotation Short name: ArgRSUniRule annotation
Gene namesⁱ	Name:argSUniRule annotation Ordered Locus Names:Asuc_1094
Organismⁱ	Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifierⁱ	339671 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus › Actinobacillus succinogenes
Proteomesⁱ	UP000001114 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00123

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000071392	1 – 575	Arginine--tRNA ligaseAdd BLAST		575

Interactionⁱ

Subunit structureⁱ

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	339671.Asuc_1094

STRINGⁱ

339671.Asuc_1094

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6VNB3
SMRⁱ	A6VNB3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	122 – 132	"HIGH" regionAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105C75 Bacteria COG0018 LUCA
HOGENOMⁱ	HOG000247212
KEGG Orthology (KO) More...KOⁱ	K01887
OMAⁱ	NKPLHLG
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01RF

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00671 ArgRS_core, 1 hit
Gene3Dⁱ	3.30.1360.701 hit 3.40.50.6201 hit
HAMAPⁱ	MF_00123 Arg_tRNA_synth, 1 hit
InterProⁱ	View protein in InterPro IPR001412 aa-tRNA-synth_I_CS IPR001278 Arg-tRNA-ligase IPR005148 Arg-tRNA-synth_N IPR036695 Arg-tRNA-synth_N_sf IPR035684 ArgRS_core IPR008909 DALR_anticod-bd IPR014729 Rossmann-like_a/b/a_fold IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERⁱ	PTHR11956 PTHR11956, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03485 Arg_tRNA_synt_N, 1 hit PF05746 DALR_1, 1 hit PF00750 tRNA-synt_1d, 1 hit
PRINTSⁱ	PR01038 TRNASYNTHARG
SMARTⁱ	View protein in SMART SM01016 Arg_tRNA_synt_N, 1 hit SM00836 DALR_1, 1 hit
SUPFAMⁱ	SSF47323 SSF47323, 1 hit SSF55190 SSF55190, 1 hit
TIGRFAMsⁱ	TIGR00456 argS, 1 hit
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A6VNB3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNIQQLLSEK IRHAMIAAGA QQPAEPAVRQ SGKPQFGDYQ ANGIMGAAKK 
        60         70         80         90        100
LGLNPREFAQ KVLDNLNLDG IAEKLEIAGP GFINIFLSKN WLVCHADEML 
       110        120        130        140        150
SAVNFGIKTA KPQTIVVDYS SPNVAKEMHV GHLRSTIIGD AVVRTLEFLG 
       160        170        180        190        200
NHVIRANHVG DWGTQFGMLI AYLEKMENEN ASAMQLSDLE AFYRAAKEHY 
       210        220        230        240        250
DNDEAFAEKA RNYVVKLQSG DEYCRIMWKK LVDITMRHNQ ENYDRLNVTL 
       260        270        280        290        300
TEKDVMGESL YNPMLPEIVA DLKKQGLAVE DDGALVVYLD EFKNKDGDPM 
       310        320        330        340        350
GVIVQKKDGG YLYTTTDIAA AKYRCHKLHA DRVLVFSDSR QSQHMQQAWL 
       360        370        380        390        400
ITRKAGYVPD SFSLEHPFFG MMLGKDGKPF KTRTGGTVKL KDLLDEAVER 
       410        420        430        440        450
ADKLIAERNP DLTAEEKAAV VEAVAIGSVK YSDLSKNRTT DYVFDWDNML 
       460        470        480        490        500
TFEGNTAPYM QYAYTRIRSI FARAGIEPNS LNDDIVLTDD KERVLVIKLL 
       510        520        530        540        550
QFEEALNGVA KDGMPHILCQ YLYELAGMFS AFYEACPILN AERPIKNSRL 
       560        570 
KLAALAAKTL KQGLDLLGIK TVEKM

Length:575

Mass (Da):64,397

Last modified:August 21, 2007 - v1

Checksum:ⁱ85399351322A9C34

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000746 Genomic DNA Translation: ABR74460.1
NCBI Reference Sequences More...RefSeqⁱ	WP_012072837.1, NC_009655.1

Genome annotation databases

EnsemblBacteriaⁱ	ABR74460; ABR74460; Asuc_1094
KEGGⁱ	asu:Asuc_1094

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A6VNB3	Q87RD6 Z2EJM0 A0A0F2GWN8 A6B4M0 A0A0D1G8L4 A0A0F6LQT4 UPI00046E5864 A0A227JHA8 B8K7M7 F7YK01 +697	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) Vibrio parahaemolyticus V-223/04 Vibrio parahaemolyticus Vibrio parahaemolyticus serotype O3:K6 (strain AQ3810) Vibrio parahaemolyticus 49 Vibrio parahaemolyticus 863 Vibrio sp. 16 Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum) Vibrio sp. V06_P1A73T115 Vibrio parahaemolyticus 901128 And more	577	UniRef50_Q87RD6	Cluster: Arginine--tRNA ligase	708

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000746 Genomic DNA Translation: ABR74460.1
NCBI Reference Sequences More...RefSeqⁱ	WP_012072837.1, NC_009655.1

3D structure databases

ProteinModelPortalⁱ	A6VNB3
SMRⁱ	A6VNB3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	339671.Asuc_1094

STRINGⁱ

339671.Asuc_1094

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABR74460; ABR74460; Asuc_1094
KEGGⁱ	asu:Asuc_1094

Phylogenomic databases

eggNOGⁱ	ENOG4105C75 Bacteria COG0018 LUCA
HOGENOMⁱ	HOG000247212
KEGG Orthology (KO) More...KOⁱ	K01887
OMAⁱ	NKPLHLG
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01RF

Enzyme and pathway databases

BioCycⁱ	ASUC339671:G1G9D-1161-MONOMER

BioCycⁱ

ASUC339671:G1G9D-1161-MONOMER

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00671 ArgRS_core, 1 hit
Gene3Dⁱ	3.30.1360.701 hit 3.40.50.6201 hit
HAMAPⁱ	MF_00123 Arg_tRNA_synth, 1 hit
InterProⁱ	View protein in InterPro IPR001412 aa-tRNA-synth_I_CS IPR001278 Arg-tRNA-ligase IPR005148 Arg-tRNA-synth_N IPR036695 Arg-tRNA-synth_N_sf IPR035684 ArgRS_core IPR008909 DALR_anticod-bd IPR014729 Rossmann-like_a/b/a_fold IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERⁱ	PTHR11956 PTHR11956, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03485 Arg_tRNA_synt_N, 1 hit PF05746 DALR_1, 1 hit PF00750 tRNA-synt_1d, 1 hit
PRINTSⁱ	PR01038 TRNASYNTHARG
SMARTⁱ	View protein in SMART SM01016 Arg_tRNA_synt_N, 1 hit SM00836 DALR_1, 1 hit
SUPFAMⁱ	SSF47323 SSF47323, 1 hit SSF55190 SSF55190, 1 hit
TIGRFAMsⁱ	TIGR00456 argS, 1 hit
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYR_ACTSZ
Accessionⁱ	A6VNB3Primary (citable) accession number: A6VNB3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	August 21, 2007
	Last modified:	February 28, 2018
	This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A6VNB3 (SYR_ACTSZ)

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Arginine--tRNA ligase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ