Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot A6VN06 (ASSY_ACTSZ)

Last modified November 3, 2009. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Argininosuccinate synthase
    EC=6.3.4.5
Alternative name(s):
    Citrulline--aspartate ligase
Gene names
Name: argG
Ordered Locus Names: Asuc_0985
OrganismActinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]
Taxonomic identifier339671 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Hide | Top

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP MF_00581

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP MF_00581

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 2 subfamily.

Hide | Top

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Argininosuccinate synthase HAMAP MF_00581
PRO_1000072589

Regions

Nucleotide binding18 – 269ATP By similarity

Sites

Binding site441ATP By similarity
Binding site1001Citrulline By similarity
Binding site1301ATP; via amide nitrogen By similarity
Binding site1321Aspartate By similarity
Binding site1321ATP By similarity
Binding site1361Aspartate By similarity
Binding site1361Citrulline By similarity
Binding site1371Aspartate By similarity
Binding site1371ATP By similarity
Binding site1401Citrulline By similarity
Binding site1931Citrulline By similarity
Binding site1951ATP By similarity
Binding site2021Citrulline By similarity
Binding site2041Citrulline By similarity
Binding site2811Citrulline By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
A6VN06-1 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 4F9CBC635B6FFBC2

FASTA44449,539
        10         20         30         40         50         60 
MSNTILQNLP EGQKVGIAFS GGLDTSAALL WMRQKGAVPY AYTANLGQPD EDDYNAIPKK 

        70         80         90        100        110        120 
AMAYGAENAR LIDCRTQLAQ EGIAAIQCGA FHISTGGVTY FNTTPLGRAV TGTMLVAAMK 

       130        140        150        160        170        180 
EDDVNIWGDG STFKGNDIER FYRYGLLTNP NLKIYKPWLD DQFIDELGGR FEMSQFLIAN 

       190        200        210        220        230        240 
GFDYKMSVEK AYSTDSNMLG ATHEAKDLED LSTGINIVKP IMGVAFWDES VEIKPEVVTV 

       250        260        270        280        290        300 
RFEEGVPVEL NGKRFDDVVE LFMEANRIGG RHGLGMSDQI ENRIIEAKSR GIYEAPGMAL 

       310        320        330        340        350        360 
FHIAYERLLT GIHNEDTIEQ YRINGLRLGR LLYQGRWFDP QALMLRESSQ RWVAKAITGE 

       370        380        390        400        410        420 
VKLELRRGND YSILDTVSPN LTYEAERLSM EKVEDAPFDP IDRIGQLTMR NLDVTDTRNK 

       430        440 
LGVYSKAGLL TAGQDAVVPQ LDKK

« Hide

Hide | Top

References

[1]"Complete sequence of Actinobacillus succinogenes 130Z."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Hide | Top

Cross-references

Sequence databases

CP000746 Genomic DNA. Translation: ABR74353.1.
RefSeqYP_001344288.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA6VN06.

Genome annotation databases

GeneID5349632.
GenomeReviewsGene locus Asuc_0985 in contig CP000746_GR.
KEGGasu:Asuc_0985.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAGGRKEMS.

Family and domain databases

HAMAPMF_00581.
[Tree]
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHERPTHR11587. Arginosuc_synth. 1 hit.
PfamPF00764. Arginosuc_synth. 2 hits.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameASSY_ACTSZ
AccessionPrimary (citable) accession number: A6VN06
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents