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Protein

Argininosuccinate synthase

Gene

argG

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei100CitrullineUniRule annotation1
Binding sitei130ATP; via amide nitrogenUniRule annotation1
Binding sitei132AspartateUniRule annotation1
Binding sitei132ATPUniRule annotation1
Binding sitei136AspartateUniRule annotation1
Binding sitei136CitrullineUniRule annotation1
Binding sitei137AspartateUniRule annotation1
Binding sitei137ATPUniRule annotation1
Binding sitei140CitrullineUniRule annotation1
Binding sitei193CitrullineUniRule annotation1
Binding sitei195ATPUniRule annotation1
Binding sitei202CitrullineUniRule annotation1
Binding sitei204CitrullineUniRule annotation1
Binding sitei281CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASUC339671:G1G9D-1030-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Asuc_0985
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000725891 – 444Argininosuccinate synthaseAdd BLAST444

Proteomic databases

PRIDEiA6VN06

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi339671.Asuc_0985

Structurei

3D structure databases

ProteinModelPortaliA6VN06
SMRiA6VN06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230094
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

Gene3Di1.10.287.400, 1 hit
3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00581 Arg_succ_synth_type2, 1 hit
InterProiView protein in InterPro
IPR023437 Arg_succ_synth_type2_subfam
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR024074 AS_cat/multimer_dom_body
IPR024073 AS_multimer_C_tail
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6VN06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTILQNLP EGQKVGIAFS GGLDTSAALL WMRQKGAVPY AYTANLGQPD
60 70 80 90 100
EDDYNAIPKK AMAYGAENAR LIDCRTQLAQ EGIAAIQCGA FHISTGGVTY
110 120 130 140 150
FNTTPLGRAV TGTMLVAAMK EDDVNIWGDG STFKGNDIER FYRYGLLTNP
160 170 180 190 200
NLKIYKPWLD DQFIDELGGR FEMSQFLIAN GFDYKMSVEK AYSTDSNMLG
210 220 230 240 250
ATHEAKDLED LSTGINIVKP IMGVAFWDES VEIKPEVVTV RFEEGVPVEL
260 270 280 290 300
NGKRFDDVVE LFMEANRIGG RHGLGMSDQI ENRIIEAKSR GIYEAPGMAL
310 320 330 340 350
FHIAYERLLT GIHNEDTIEQ YRINGLRLGR LLYQGRWFDP QALMLRESSQ
360 370 380 390 400
RWVAKAITGE VKLELRRGND YSILDTVSPN LTYEAERLSM EKVEDAPFDP
410 420 430 440
IDRIGQLTMR NLDVTDTRNK LGVYSKAGLL TAGQDAVVPQ LDKK
Length:444
Mass (Da):49,539
Last modified:August 21, 2007 - v1
Checksum:i4F9CBC635B6FFBC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000746 Genomic DNA Translation: ABR74353.1
RefSeqiWP_012072730.1, NC_009655.1

Genome annotation databases

EnsemblBacteriaiABR74353; ABR74353; Asuc_0985
KEGGiasu:Asuc_0985

Similar proteinsi

Entry informationi

Entry nameiASSY_ACTSZ
AccessioniPrimary (citable) accession number: A6VN06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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