Reviewed, UniProtKB/Swiss-Prot A6VMY7 (AROC_ACTSZ)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	Asuc_0966

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Chorismate synthase HAMAP MF_00300		PRO_1000071964

Sequences

	Sequence		Length	Mass (Da)
	A6VMY7-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: E413021353257FCA	FASTA	360	38,967
	10 20 30 40 50 60 MAGNSIGQLF RVTTFGESHG IALGCIVDGV PPNMALSEAD IQPDLDRRKP GTSRYTTARR 70 80 90 100 110 120 EADEIQILSG VFEGKTTGTS IGLIIKNADQ RSKDYGDIMD KFRPGHADYT YQQKYGIRDY 130 140 150 160 170 180 RGGGRSSARE TAMRVAAGAI AKKYLRERFG IEIRGYLSQI GEVKIDPQTV ADVTKINWQQ 190 200 210 220 230 240 VADNPFFCPD KSAVEKFDEL IRKLKKEGNS IGAKLTVVAE NVPVGLGEPV FDRLDAELAH 250 260 270 280 290 300 ALMGINAVKA VEIGDGFDVV AQKGTEHRDE MTPAGFLSNH AGGILGGISN GQPIIATIAL 310 320 330 340 350 360 KPTSSITIPG RTVDINNKPV ELITKGRHDP CVGIRAVPIA EAMVAIILLD HLLRFKAQCK

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000746 Genomic DNA. Translation: ABR74334.1.
RefSeq	YP_001344269.1.
3D structure databases
SMR	A6VMY7. Positions 4-357.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VMY7.
Genome annotation databases
GeneID	5348759.
GenomeReviews	Gene locus Asuc_0966 in contig CP000746_GR.
KEGG	asu:Asuc_0966.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
OMA	SRFTTQR.
Family and domain databases
HAMAP	MF_00300_B. Chorismate_synth_B. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ACTSZ

Accession

Primary (citable) accession number: A6VMY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	February 9, 2010
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)