Reviewed, UniProtKB/Swiss-Prot A6VMV2 (PROA_ACTSZ)

Names and origin

Protein names

Recommended name:
    Gamma-glutamyl phosphate reductase
      Short name=GPR
    EC=1.2.1.41
Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenase
    Glutamyl-gamma-semialdehyde dehydrogenase
      Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	Asuc_0931

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Gamma-glutamyl phosphate reductase		PRO_1000072277

Sequences

	Sequence		Length	Mass (Da)
	A6VMV2-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: D11013433856BC4E	FASTA	416	45,186
	10 20 30 40 50 60 MTNLEVMGKA ARQAAFELSQ LSAGDKNYAL QMIAEQLESQ QQQILAANAR DIDEARINGL 70 80 90 100 110 120 NDAIIDRLLL TPERLRGIAN DVRHVISLAD PVGKLIDGGI LDSGLKLERI RVPVGVIGTI 130 140 150 160 170 180 YEARPNVTID VASLCLKTGN AVILRGGKET RHSNRILVEV VQNALEKAGL PKTAVQAITD 190 200 210 220 230 240 PDRALVMELL KLDRYVDMII PRGGAGLHAL CKQHATIPVI IGGIGVCHTF VEQSADQNRA 250 260 270 280 290 300 ISVIKNAKTQ RPSTCNTLET LLIQESIAHE FLPKLAAELP VKYYADKTAY SILHHAGAEV 310 320 330 340 350 360 LAVTEDDLRK EWLCTNLNVV IVQDIEAAVA HIREYGSQHS EAILTESLQL ARRFVAQVDS 370 380 390 400 410 AAVYVNASTR FTDGGQFGLG AEVAVSTQKL HARGPMGLEA LTTYKWVATG DYTVRS

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR74299.1.
RefSeq	YP_001344234.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5348169.
GenomeReviews	Gene locus Asuc_0931 in contig CP000746_GR.
KEGG	asu:Asuc_0931.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00412. [Tree]
InterPro	IPR016163. Ald_DHase_C. IPR016162. Ald_DHase_N. IPR000965. Gglut_pp_reduct. IPR012134. Glu-5-SA_DHase. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
PIRSF	PIRSF000151. GPR. 1 hit.
TIGRFAMs	TIGR00407. proA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_ACTSZ

Accession

Primary (citable) accession number: A6VMV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 25, 2008
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)