Reviewed, UniProtKB/Swiss-Prot A6VMU5 (AROA_ACTSZ)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Asuc_0924

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000071734

Sequences

	Sequence		Length	Mass (Da)
	A6VMU5-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: EA8079B4C81367F5	FASTA	433	47,146
	10 20 30 40 50 60 MEKITLNPIA RVEGTVNLPG SKSLSNRALL LAALAKGTTK VTNLLDSDDV RHMLNALKRL 70 80 90 100 110 120 GVSYTLSDDK TVCEVQGLGR AFEWQNGLSL FLGNAGTAMR PLTAALCLAN SGNESPAEIV 130 140 150 160 170 180 LTGEPRMKER PIKHLVDALL QAGAEIEYLE QDGYPPLAIR NKGLHGGKVK IDGSVSSQFL 190 200 210 220 230 240 TALLMAAPMS AADTEIEIIG DLVSKPYIDI TLNMMKIFGV EVENRNYQRF TVKGCQQYQS 250 260 270 280 290 300 PKTFLVEGDA SSASYFLAAG AIKGCVKVTG VGKNSIQGDR LFADVLTAMG AKITWGEDFI 310 320 330 340 350 360 RAEQGELSGV DMDMNHIPDA AMTIATAALF AKGETVIRNI YNWRVKETDR LAAMATELRK 370 380 390 400 410 420 VGATVEEGED FIRIQPLPLA EFKHAEIETY NDHRMAMCFA LIALSDTPVT ILDPKCTAKT 430 FPTFFDEFSR ISQ

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR74292.1.
RefSeq	YP_001344227.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VMU5.
Genome annotation databases
GeneID	5349591.
GenomeReviews	Gene locus Asuc_0924 in contig CP000746_GR.
KEGG	asu:Asuc_0924.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EIDTYND.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_ACTSZ

Accession

Primary (citable) accession number: A6VMU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)