Reviewed, UniProtKB/Swiss-Prot A6VMR4 (ARGA_ACTSZ)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	Asuc_0891

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subcellular location	Cytoplasm By similarity.
Miscellaneous	In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (argJ), argA fulfills an anaplerotic role. HAMAP MF_01105
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	amino-acid N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	Amino-acid acetyltransferase HAMAP MF_01105		PRO_1000084808
Regions
	Domain	289 – 429	141	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	A6VMR4-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: CBC69A07381735E5	FASTA	440	50,161
	10 20 30 40 50 60 MRSTELVQWF RQSTPYVNMH RGKTFVIMLD GDTIASENFI NIISDIRLLH SLGIKLIIVF 70 80 90 100 110 120 GARFQINDLL MKNHIRPVYH KNIRVTDLRT LELVKQAAGQ LNYDIMSRLS MRLPHSPLLN 130 140 150 160 170 180 VVSSNFILAQ PIGVDDGVDY MLSGKLRRIE VENIKQQLEN DAIVLIGPVA PSVTGESFNL 190 200 210 220 230 240 PFEEVATQVA IKLKAEKLIG FSNTQGILDK DGVSIPDLLP QQAANYLQQF IERDQYHSSQ 250 260 270 280 290 300 ARFLQAAIDV CRAGVHRSHL LSYEEDGSLL QELFTRDGVG TQLSMESSED IRIATARDIP 310 320 330 340 350 360 SLLELIHPLE QQGILVKRSR EQLEMDIEKY TIIDRDGVII ACAALNVYED EKMAEMACVA 370 380 390 400 410 420 VHPDYRSSSR GDVLLAEIRK RAKNLDIEKL FVLTTRTVHW FQERGFHMAN VEDLPKDKRD 430 440 HYNYQRRSKI LIQNLTEPSE

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR74261.1.
RefSeq	YP_001344196.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VMR4.
Genome annotation databases
GeneID	5348802.
GenomeReviews	Gene locus Asuc_0891 in contig CP000746_GR.
KEGG	asu:Asuc_0891.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DLIRPLE.
Family and domain databases
HAMAP	MF_01105. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_ACTSZ

Accession

Primary (citable) accession number: A6VMR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)