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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei622ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASUC339671:G1G9D-778-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Asuc_0743
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001114 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000711071 – 860Leucine--tRNA ligaseAdd BLAST860

Proteomic databases

PRIDEiA6VMB8

Interactioni

Protein-protein interaction databases

STRINGi339671.Asuc_0743

Structurei

3D structure databases

ProteinModelPortaliA6VMB8
SMRiA6VMB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi619 – 623"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A6VMB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYRPDLI EAEVQKYWQE NKTFKAIKDT NKEKYYCLSM LPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRYQRMIG KNVLQPMGWD AFGLPAEGAA VKNNTAPAKW
110 120 130 140 150
TYENIEYMKN QLKVLGFSYD WEREVTTCRP EYYKWEQWFF TELYKKGLVY
160 170 180 190 200
KKTSVVNWCP NDETVLANEQ VHEGCCWRCD TPVEQREIPQ WFIKITDYAE
210 220 230 240 250
QLLGGLDTLP EWPEMVKTMQ RNWIGRSEGV EITFKIENSD ETVAVYTTRP
260 270 280 290 300
DTFYGVSYMA VAAGHPLAER AAQNNPDLAK FIQECKNTKV AEAELATMEK
310 320 330 340 350
KGMATGLNAV HPITGKPVPI WVANFVLMHY GTGAVMAVPA HDQRDFEFAT
360 370 380 390 400
KYDLPINQVI APVNGEDIDL SKAAFTEHGK LVNSAEFDGL DFDAAFNGIA
410 420 430 440 450
DKLERMGAGK RQVNYRLRDW GVSRQRYWGA PIPMLTLENG DVVPAPLQDL
460 470 480 490 500
PIVLPEDVVM DGVKSPIKAD PDWAKTTYNG RPALKETDTF DTFMESSWYY
510 520 530 540 550
ARYTCPQYHE GMLDSEEANY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD
560 570 580 590 600
AGLVSTDEPT KKLLCQGMVL ADAFYYTSPT NERIWVSPTK VTLERDEKGR
610 620 630 640 650
IVKALDDEGR ELVHAGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWQE SGVEGAKRFL GRLWNLVFEY NKNPAKTALN PTALSGVQKA
710 720 730 740 750
LRRGVHKTIA KVSDDIGRRQ TFNTAIAAIM ELMNKLTRAS LAGEQDRAIM
760 770 780 790 800
GEALSAVVRM LYPITPHVCF QLWKELGNED VIDFAPWVQA DEAAMVEEEK
810 820 830 840 850
LVVVQVNGKV RGKITVPADM AEDDIKQAAL ADENVQKFLS GLNIVKTIYV
860
PGKLFSFVAK
Length:860
Mass (Da):97,643
Last modified:August 21, 2007 - v1
Checksum:iDCAD14949EAB5A53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000746 Genomic DNA Translation: ABR74115.1
RefSeqiWP_012072494.1, NC_009655.1

Genome annotation databases

EnsemblBacteriaiABR74115; ABR74115; Asuc_0743
KEGGiasu:Asuc_0743

Similar proteinsi

Entry informationi

Entry nameiSYL_ACTSZ
AccessioniPrimary (citable) accession number: A6VMB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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