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A6VMB8

- SYL_ACTSZ

UniProt

A6VMB8 - SYL_ACTSZ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASUC339671:GHDX-775-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Asuc_0743
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001114: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligasePRO_1000071107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi339671.Asuc_0743.

Structurei

3D structure databases

ProteinModelPortaliA6VMB8.
SMRiA6VMB8. Positions 228-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VMB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYRPDLI EAEVQKYWQE NKTFKAIKDT NKEKYYCLSM LPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRYQRMIG KNVLQPMGWD AFGLPAEGAA VKNNTAPAKW
110 120 130 140 150
TYENIEYMKN QLKVLGFSYD WEREVTTCRP EYYKWEQWFF TELYKKGLVY
160 170 180 190 200
KKTSVVNWCP NDETVLANEQ VHEGCCWRCD TPVEQREIPQ WFIKITDYAE
210 220 230 240 250
QLLGGLDTLP EWPEMVKTMQ RNWIGRSEGV EITFKIENSD ETVAVYTTRP
260 270 280 290 300
DTFYGVSYMA VAAGHPLAER AAQNNPDLAK FIQECKNTKV AEAELATMEK
310 320 330 340 350
KGMATGLNAV HPITGKPVPI WVANFVLMHY GTGAVMAVPA HDQRDFEFAT
360 370 380 390 400
KYDLPINQVI APVNGEDIDL SKAAFTEHGK LVNSAEFDGL DFDAAFNGIA
410 420 430 440 450
DKLERMGAGK RQVNYRLRDW GVSRQRYWGA PIPMLTLENG DVVPAPLQDL
460 470 480 490 500
PIVLPEDVVM DGVKSPIKAD PDWAKTTYNG RPALKETDTF DTFMESSWYY
510 520 530 540 550
ARYTCPQYHE GMLDSEEANY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD
560 570 580 590 600
AGLVSTDEPT KKLLCQGMVL ADAFYYTSPT NERIWVSPTK VTLERDEKGR
610 620 630 640 650
IVKALDDEGR ELVHAGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWQE SGVEGAKRFL GRLWNLVFEY NKNPAKTALN PTALSGVQKA
710 720 730 740 750
LRRGVHKTIA KVSDDIGRRQ TFNTAIAAIM ELMNKLTRAS LAGEQDRAIM
760 770 780 790 800
GEALSAVVRM LYPITPHVCF QLWKELGNED VIDFAPWVQA DEAAMVEEEK
810 820 830 840 850
LVVVQVNGKV RGKITVPADM AEDDIKQAAL ADENVQKFLS GLNIVKTIYV
860
PGKLFSFVAK
Length:860
Mass (Da):97,643
Last modified:August 21, 2007 - v1
Checksum:iDCAD14949EAB5A53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000746 Genomic DNA. Translation: ABR74115.1.
RefSeqiWP_012072494.1. NC_009655.1.
YP_001344050.1. NC_009655.1.

Genome annotation databases

EnsemblBacteriaiABR74115; ABR74115; Asuc_0743.
GeneIDi5349532.
KEGGiasu:Asuc_0743.
PATRICi20759750. VBIActSuc117883_0785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000746 Genomic DNA. Translation: ABR74115.1 .
RefSeqi WP_012072494.1. NC_009655.1.
YP_001344050.1. NC_009655.1.

3D structure databases

ProteinModelPortali A6VMB8.
SMRi A6VMB8. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 339671.Asuc_0743.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR74115 ; ABR74115 ; Asuc_0743 .
GeneIDi 5349532.
KEGGi asu:Asuc_0743.
PATRICi 20759750. VBIActSuc117883_0785.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ASUC339671:GHDX-775-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production."
    McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A., Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L., Burkhart K.B., Harkins V., Vieille C.
    BMC Genomics 11:680-680(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 55618 / 130Z.

Entry informationi

Entry nameiSYL_ACTSZ
AccessioniPrimary (citable) accession number: A6VMB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3