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A6VMA4

- PUR5_ACTSZ

UniProt

A6VMA4 - PUR5_ACTSZ

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASUC339671:GHDX-761-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Asuc_0729
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001114: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000072813Add
BLAST

Proteomic databases

PRIDEiA6VMA4.

Interactioni

Protein-protein interaction databases

STRINGi339671.Asuc_0729.

Structurei

3D structure databases

ProteinModelPortaliA6VMA4.
SMRiA6VMA4. Positions 5-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A6VMA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKQSLSYKD AGVDINAGNE LVERIKPHVK RTTRSEVIGG LGGFGALCAL
60 70 80 90 100
PAKYKEPVLV SGTDGVGTKL RLAIDLKKHD TIGIDLVAMC VNDLVVQGAE
110 120 130 140 150
PLFFLDYYAT GKLDVDVAAD VVKGIAEGCV QSSCALVGGE TAEMPGMYRE
160 170 180 190 200
GDYDLAGFCV GVVEKSKILD GSKVQAGDAL IALASSGPHS NGYSLVRKVI
210 220 230 240 250
EVAGVNPATE QLAGKPLAEQ VLAPTKIYVK SVLELIEKTD VHAIAHLTGG
260 270 280 290 300
GFWENIPRVL PENVKAVIDE TSWDWQPVFK WLQEQGNITR HEMYRTFNCG
310 320 330 340
VGMVLALPQA EADKALDILR AAGENAWLIG RIEALNAGEQ QVIIR
Length:345
Mass (Da):36,953
Last modified:August 21, 2007 - v1
Checksum:i693EBC18ACE4C337
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000746 Genomic DNA. Translation: ABR74101.1.
RefSeqiWP_012072480.1. NC_009655.1.
YP_001344036.1. NC_009655.1.

Genome annotation databases

EnsemblBacteriaiABR74101; ABR74101; Asuc_0729.
GeneIDi5348702.
KEGGiasu:Asuc_0729.
PATRICi20759720. VBIActSuc117883_0770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000746 Genomic DNA. Translation: ABR74101.1 .
RefSeqi WP_012072480.1. NC_009655.1.
YP_001344036.1. NC_009655.1.

3D structure databases

ProteinModelPortali A6VMA4.
SMRi A6VMA4. Positions 5-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 339671.Asuc_0729.

Proteomic databases

PRIDEi A6VMA4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR74101 ; ABR74101 ; Asuc_0729 .
GeneIDi 5348702.
KEGGi asu:Asuc_0729.
PATRICi 20759720. VBIActSuc117883_0770.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci ASUC339671:GHDX-761-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production."
    McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A., Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L., Burkhart K.B., Harkins V., Vieille C.
    BMC Genomics 11:680-680(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 55618 / 130Z.

Entry informationi

Entry nameiPUR5_ACTSZ
AccessioniPrimary (citable) accession number: A6VMA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3