Reviewed, UniProtKB/Swiss-Prot A6VMA4 (PUR5_ACTSZ)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	Asuc_0729

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_1000072813

Sequences

	Sequence		Length	Mass (Da)
	A6VMA4-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 693EBC18ACE4C337	FASTA	345	36,953
	10 20 30 40 50 60 MSKQSLSYKD AGVDINAGNE LVERIKPHVK RTTRSEVIGG LGGFGALCAL PAKYKEPVLV 70 80 90 100 110 120 SGTDGVGTKL RLAIDLKKHD TIGIDLVAMC VNDLVVQGAE PLFFLDYYAT GKLDVDVAAD 130 140 150 160 170 180 VVKGIAEGCV QSSCALVGGE TAEMPGMYRE GDYDLAGFCV GVVEKSKILD GSKVQAGDAL 190 200 210 220 230 240 IALASSGPHS NGYSLVRKVI EVAGVNPATE QLAGKPLAEQ VLAPTKIYVK SVLELIEKTD 250 260 270 280 290 300 VHAIAHLTGG GFWENIPRVL PENVKAVIDE TSWDWQPVFK WLQEQGNITR HEMYRTFNCG 310 320 330 340 VGMVLALPQA EADKALDILR AAGENAWLIG RIEALNAGEQ QVIIR

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR74101.1.
RefSeq	YP_001344036.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VMA4.
Genome annotation databases
GeneID	5348702.
GenomeReviews	Gene locus Asuc_0729 in contig CP000746_GR.
KEGG	asu:Asuc_0729.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VHGLAHI.
Family and domain databases
HAMAP	MF_00741. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_ACTSZ

Accession

Primary (citable) accession number: A6VMA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)