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Protein

Membrane-bound lytic murein transglycosylase C

Gene

mltC

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.UniRule annotation

Catalytic activityi

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciASUC339671:G1G9D-567-MONOMER

Protein family/group databases

CAZyiGH23 Glycoside Hydrolase Family 23

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lytic murein transglycosylase CUniRule annotation (EC:4.2.2.n1UniRule annotation)
Alternative name(s):
Murein lyase CUniRule annotation
Gene namesi
Name:mltCUniRule annotation
Ordered Locus Names:Asuc_0542
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001114 Componenti: Chromosome

Subcellular locationi

  • Cell outer membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19UniRule annotationAdd BLAST19
ChainiPRO_500025872920 – 358Membrane-bound lytic murein transglycosylase CAdd BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteineUniRule annotation1
Lipidationi20S-diacylglycerol cysteineUniRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiA6VLS0

Interactioni

Protein-protein interaction databases

STRINGi339671.Asuc_0542

Structurei

3D structure databases

ProteinModelPortaliA6VLS0
SMRiA6VLS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transglycosylase Slt family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106S48 Bacteria
COG0741 LUCA
HOGENOMiHOG000283572
KOiK08306
OMAiAIMQIES
OrthoDBiPOG091H06EG

Family and domain databases

HAMAPiMF_01616 MltC, 1 hit
InterProiView protein in InterPro
IPR023346 Lysozyme-like_dom_sf
IPR023664 Murein_transglycosylaseC
IPR024570 Murein_transglycosylaseC_N
IPR000189 Transglyc_AS
IPR008258 Transglycosylase_SLT_dom_1
PfamiView protein in Pfam
PF11873 DUF3393, 1 hit
PF01464 SLT, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
PS00922 TRANSGLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6VLS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITLKKLLI LAIVPFLYAC SSDRANYDDV FAKDTHGLDL LTGQFSQNID
60 70 80 90 100
QIWGVNELLV ASRKDYVKYN DSYYTRSHIS FDEGMITIET LADVNRLHSA
110 120 130 140 150
IVHTLLMGSD AKGIDLFASG DTPISSRPFL VGQVVNNFGQ SITNVNVANN
160 170 180 190 200
FATYLIQNKL QQRRLNNGRT VQFVSIQMIA NHVNIRARKY LPFVRKASRQ
210 220 230 240 250
YGIDESLILG IMQTESSFNP YAISYANAIG LMQVVPHSAG RDIFKMKGRS
260 270 280 290 300
GQPSKSYLFD PAKNVDAGTS YLWLLRNEYL AGIQNPTSMR YAMISAYNSG
310 320 330 340 350
AGAVLRVFSD DPDEAIYIIN RMQPEQVYRI LTTGHPSAQA RNYLVKVDKA

QRSYRRVR
Length:358
Mass (Da):40,321
Last modified:August 21, 2007 - v1
Checksum:i0261F82FC00A8DEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000746 Genomic DNA Translation: ABR73917.1
RefSeqiWP_012072297.1, NC_009655.1

Genome annotation databases

EnsemblBacteriaiABR73917; ABR73917; Asuc_0542
KEGGiasu:Asuc_0542

Similar proteinsi

Entry informationi

Entry nameiMLTC_ACTSZ
AccessioniPrimary (citable) accession number: A6VLS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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