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A6VLR7

- TRMB_ACTSZ

UniProt

A6VLR7 - TRMB_ACTSZ

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801S-adenosyl-L-methionineUniRule annotation
Binding sitei105 – 1051S-adenosyl-L-methionineUniRule annotation
Binding sitei132 – 1321S-adenosyl-L-methionineUniRule annotation
Active sitei155 – 1551By similarity
Binding sitei155 – 1551S-adenosyl-L-methionineUniRule annotation
Binding sitei159 – 1591SubstrateUniRule annotation
Binding sitei191 – 1911SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciASUC339671:GHDX-561-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Asuc_0539
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001114: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252tRNA (guanine-N(7)-)-methyltransferasePRO_1000072994Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi339671.Asuc_0539.

Structurei

3D structure databases

ProteinModelPortaliA6VLR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni231 – 2344Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiHSTLEMA.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VLR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELKKTFAD QKRKTVETAE FTEDGRYKRK IRSFVLRTGR LSEYQRQMMN
60 70 80 90 100
DNWSNYGLDY QTEPFDFPAI YGNHNPVILE IGFGMGKSLV EMAQQNPDKN
110 120 130 140 150
YLGIEVHTPG VGACLAYALE KGIKNLRVIC HDATEILRDC IADRSLGGLQ
160 170 180 190 200
LFFPDPWHKA KHHKRRIVQP QFVKTVTQKL TSGGFIHFAT DWQNYAEHML
210 220 230 240 250
NVLQSVQSAV GIRNISETGD FIPRPDFRPL TKFEQRGQKL GHGIWDLYFI

KN
Length:252
Mass (Da):29,082
Last modified:August 21, 2007 - v1
Checksum:i51E9BC580F50A723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000746 Genomic DNA. Translation: ABR73914.1.
RefSeqiWP_012072294.1. NC_009655.1.
YP_001343849.1. NC_009655.1.

Genome annotation databases

EnsemblBacteriaiABR73914; ABR73914; Asuc_0539.
GeneIDi5348552.
KEGGiasu:Asuc_0539.
PATRICi20759302. VBIActSuc117883_0571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000746 Genomic DNA. Translation: ABR73914.1 .
RefSeqi WP_012072294.1. NC_009655.1.
YP_001343849.1. NC_009655.1.

3D structure databases

ProteinModelPortali A6VLR7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 339671.Asuc_0539.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR73914 ; ABR73914 ; Asuc_0539 .
GeneIDi 5348552.
KEGGi asu:Asuc_0539.
PATRICi 20759302. VBIActSuc117883_0571.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi HSTLEMA.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci ASUC339671:GHDX-561-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production."
    McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A., Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L., Burkhart K.B., Harkins V., Vieille C.
    BMC Genomics 11:680-680(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 55618 / 130Z.

Entry informationi

Entry nameiTRMB_ACTSZ
AccessioniPrimary (citable) accession number: A6VLR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3