A6VLM2 (ARAA_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	Asuc_0494

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	L-arabinose isomerase HAMAP MF_00519		PRO_1000072489
Sites
	Metal binding	305	1	Manganese By similarity
	Metal binding	332	1	Manganese By similarity
	Metal binding	349	1	Manganese By similarity
	Metal binding	448	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6VLM2 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: CF2F681E5C369C98	FASTA	495	56,099
	10 20 30 40 50 60 MEFIKKLEVW FIVGSQDLYG DEALKQVYAN AKQITQYLNS RNPFIQIKLK PLATTPEDIL 70 80 90 100 110 120 AICRAANYEE NCAGVIAWMH TFSPAKMWIA GLTRLDKPLL QFHTQFNKYI PWNEIDMDYM 130 140 150 160 170 180 NLHQTAHGDR EFGFMVSRLR KPRTIVVGHW QSESVKQKLD RWMRVLAAIY DQQHLKVARF 190 200 210 220 230 240 GDNMREVAVT EGDKVEAQIK FGYSVNGYGI YQLVNSINAI KEEDIATLVK EYEADYQLVD 250 260 270 280 290 300 SLKEGGEKRQ SLIDSARIEL GLKAFLDKGG FKAFTDTFQN LYGMKQLPGL PVQRLMAQGY 310 320 330 340 350 360 GFGAEGDWKT AALVRAIKVM SYGLPNGCSF MEDYTYNLED HNEVVLAAHM LEVCPSIAED 370 380 390 400 410 420 KPILDIKPLG IGGKEDPTRL IFTSKAGCAT ASTIVDLGNR FRMITAELQA IAKPQDMPNL 430 440 450 460 470 480 PVGHAFWKLE PDFDTGTQAW ILAGGAHHNV FSLDIDADML RTFAEYFGIE FIHIHAKTEL 490 ADLKNELRWN DVAYK

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000746 Genomic DNA. Translation: ABR73869.1.
RefSeq	YP_001343804.1. NC_009655.1.
3D structure databases
ProteinModelPortal	A6VLM2.
SMR	A6VLM2. Positions 1-495.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VLM2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5348082.
GenomeReviews	Gene locus Asuc_0494 in contig CP000746_GR.
KEGG	asu:Asuc_0494.
PATRIC	20759204. VBIActSuc117883_0526.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	EVCPTIA.
ProtClustDB	PRK02929.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_ACTSZ

Accession

Primary (citable) accession number: A6VLM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program