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Protein

Cytidine deaminase

Gene

cdd

Organism
Actinobacillus succinogenes (strain ATCC 55618 / 130Z)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi106Zinc; catalyticUniRule annotation1
Active sitei108Proton donorUniRule annotation1
Metal bindingi133Zinc; catalyticUniRule annotation1
Metal bindingi136Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciASUC339671:G1G9D-445-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminaseUniRule annotation (EC:3.5.4.5UniRule annotation)
Alternative name(s):
Cytidine aminohydrolaseUniRule annotation
Short name:
CDAUniRule annotation
Gene namesi
Name:cddUniRule annotation
Ordered Locus Names:Asuc_0425
OrganismiActinobacillus succinogenes (strain ATCC 55618 / 130Z)
Taxonomic identifieri339671 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001114 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000735811 – 296Cytidine deaminaseAdd BLAST296

Proteomic databases

PRIDEiA6VLF5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi339671.Asuc_0425

Structurei

3D structure databases

ProteinModelPortaliA6VLF5
SMRiA6VLF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 172CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd BLAST121
Domaini191 – 296CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 95Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T42 Bacteria
COG0295 LUCA
HOGENOMiHOG000218617
KOiK01489
OMAiGHIDAQQ
OrthoDBiPOG091H026Y

Family and domain databases

HAMAPiMF_01558 Cyt_deam, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR013171 Cyd/dCyd_deaminase_Zn-bd
IPR016193 Cytidine_deaminase-like
IPR020797 Cytidine_deaminase_bacteria
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
PF08211 dCMP_cyt_deam_2, 1 hit
SUPFAMiSSF53927 SSF53927, 2 hits
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 2 hits

Sequencei

Sequence statusi: Complete.

A6VLF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDCIGKRLD KLINESQDEV LKRVVGQILE QNGKARISQD WVRRCGDDFN
60 70 80 90 100
LTAVELALRC LPVAACYASA PVSHFNVGAV AVGQSGAFYF GANQEFSGDA
110 120 130 140 150
VQQTVHAEQS AVSHAWLAGE VALTDMVVNY TPCGHCRQFM NELNSADRLQ
160 170 180 190 200
IHLPHSRNNR LHSYLPDAFG PKDLNISRVL FDPQPHSFGF THADPLVQAA
210 220 230 240 250
ADAAEQAYAP YSRALSGVAL QVGTQSITGR YAENAAFNPS FLPLQCALNY
260 270 280 290
RRLSGLSDVP VSRIVMAESQ GGLSHRSITE QLAHSYLGLE IEYFAL
Length:296
Mass (Da):32,334
Last modified:August 21, 2007 - v1
Checksum:iF5D732B6BCA52037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000746 Genomic DNA Translation: ABR73802.1
RefSeqiWP_012072187.1, NC_009655.1

Genome annotation databases

EnsemblBacteriaiABR73802; ABR73802; Asuc_0425
KEGGiasu:Asuc_0425

Similar proteinsi

Entry informationi

Entry nameiCDD_ACTSZ
AccessioniPrimary (citable) accession number: A6VLF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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