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A6VLF5 (CDD_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytidine deaminase
EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Short name=CDA
Gene names
Name:cdd
Ordered Locus Names:Asuc_0425
OrganismActinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]
Taxonomic identifier339671 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558

Catalytic activity

Cytidine + H2O = uridine + NH3. HAMAP MF_01558

Cofactor

Binds 1 zinc ion By similarity. HAMAP MF_01558

Subunit structure

Homodimer By similarity. HAMAP MF_01558

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncytidine deaminase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Cytidine deaminase HAMAP MF_01558
PRO_1000073581

Regions

Region93 – 953Substrate binding By similarity

Sites

Active site1081Proton donor By similarity
Metal binding1061Zinc; catalytic By similarity
Metal binding1331Zinc; catalytic By similarity
Metal binding1361Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
A6VLF5 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: F5D732B6BCA52037

FASTA29632,334
        10         20         30         40         50         60 
MNDCIGKRLD KLINESQDEV LKRVVGQILE QNGKARISQD WVRRCGDDFN LTAVELALRC 

        70         80         90        100        110        120 
LPVAACYASA PVSHFNVGAV AVGQSGAFYF GANQEFSGDA VQQTVHAEQS AVSHAWLAGE 

       130        140        150        160        170        180 
VALTDMVVNY TPCGHCRQFM NELNSADRLQ IHLPHSRNNR LHSYLPDAFG PKDLNISRVL 

       190        200        210        220        230        240 
FDPQPHSFGF THADPLVQAA ADAAEQAYAP YSRALSGVAL QVGTQSITGR YAENAAFNPS 

       250        260        270        280        290 
FLPLQCALNY RRLSGLSDVP VSRIVMAESQ GGLSHRSITE QLAHSYLGLE IEYFAL

« Hide

References

[1]"Complete sequence of Actinobacillus succinogenes 130Z."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000746 Genomic DNA. Translation: ABR73802.1.
RefSeqYP_001343737.1. NC_009655.1.

3D structure databases

ProteinModelPortalA6VLF5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6VLF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5349355.
GenomeReviewsGene locus Asuc_0425 in contig CP000746_GR.
KEGGasu:Asuc_0425.
PATRIC20759056. VBIActSuc117883_0452.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0295.
HOGENOMHBG591160.
OMANRSHAPY.
ProtClustDBPRK09027.

Family and domain databases

HAMAPMF_01558. Cyt_deam.
[Tree]
InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
KOK01489.
PANTHERPTHR11644:SF12. PTHR11644:SF12. 1 hit.
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMSSF53927. Cytidine_deaminase-like. 2 hits.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_ACTSZ
AccessionPrimary (citable) accession number: A6VLF5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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