Reviewed, UniProtKB/Swiss-Prot A6VL68 (AROE_ACTSZ)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Asuc_0337

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7.
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Shikimate dehydrogenase		PRO_0000325095
Regions
	Nucleotide binding	126 – 130	5	NADP By similarity
Sites
	Active site	65	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A6VL68-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: B8296B93544E9C3C	FASTA	269	29,758
	10 20 30 40 50 60 MDNYAVWGNP IKQSKSPQIH KIFAEQTKQC MEYKAILGDP EKFETELLRF FADGAKGCNI 70 80 90 100 110 120 TAPFKERAYS LADEYSERAL TAEACNTLKR LQDGRLYADN TDGAGLVSDL ERLGWLKSKQ 130 140 150 160 170 180 SLLIIGAGGA TKGVLLPLLQ AQQNITLCNR TLTKARDLAD KFAPYGNIQA MKLSEIPVQK 190 200 210 220 230 240 FDLVINATSL GLQGKTVDIE PEILRLAGAV YDMQYDKGKD TPFVAWAKAL GVQNVHDGFG 250 260 MLVGQAAHSF YLWRGIMPDI KPLLENDLI

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR73715.1.
RefSeq	YP_001343650.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5349574.
GenomeReviews	Gene locus Asuc_0337 in contig CP000746_GR.
KEGG	asu:Asuc_0337.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR011342. Quinate/shikimate_5-DHase. IPR013708. Shikimate_DHase-bd_N. IPR006151. Shikm_DHase/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_ACTSZ

Accession

Primary (citable) accession number: A6VL68

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	August 21, 2007
Last modified:	November 25, 2008
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)