Reviewed, UniProtKB/Swiss-Prot A6VKZ5 (AROB_ACTSZ)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Asuc_0263

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094446

Sequences

	Sequence		Length	Mass (Da)
	A6VKZ5-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: DC92392EF9DD6FEF	FASTA	362	39,580
	10 20 30 40 50 60 MQCVNVELKE RRYPIYIGEG LLTDSSVYPL KSGDKVMIVT NETIAPLYLE TVTDTLNQIG 70 80 90 100 110 120 CQVSHVLLKD GEKYKTLGSL NQIFTALLQE NHGRDTTLIA LGGGVIGDVA GYAAASYQRG 130 140 150 160 170 180 IKFIQIPTTL LSQVDSSVGG KTAVNHELGK NMIGAFYQPI TVIIDTTTLN TLPKREVNAG 190 200 210 220 230 240 LAEVIKYGAI LDYPFFEWLE RHIDNLVALN QQDLQYCIAR CCRIKADVVA RDETEKGDRA 250 260 270 280 290 300 LLNLGHTFGH AIETHLGYGN WLHGEAVAAG SMMAAALSEK LGNLARTDVA RVEKLFARAN 310 320 330 340 350 360 LPTLSPDGMQ PEDYLPHMMR DKKVLAGKLR LVLLKALGQA YVATDTDPAL VLDAIYACTQ TD

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR73642.1.
RefSeq	YP_001343577.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VKZ5.
Genome annotation databases
GeneID	5348593.
GenomeReviews	Gene locus Asuc_0263 in contig CP000746_GR.
KEGG	asu:Asuc_0263.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EDYLPHM.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ACTSZ

Accession

Primary (citable) accession number: A6VKZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)