A6VKY6 (ARGB_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Asuc_0254

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000071215
Regions
	Region	43 – 44	2	Substrate binding By similarity
Sites
	Binding site	65	1	Substrate By similarity
	Binding site	157	1	Substrate By similarity
	Site	7	1	Transition state stabilizer By similarity
	Site	216	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6VKY6 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: EAB40218740CDAC8	FASTA	257	27,087
	10 20 30 40 50 60 MRPLVIKLGG ILLDTPAAME NLFNALAKYL QNSDRSLLIV HGGGCVVDDL MKRLNLPVRK 70 80 90 100 110 120 KNGLRVTPSD QIDIIVGALA GIANKTLVAQ AAKFKLNPVG LCLGDGELTA AKQFDPELGH 130 140 150 160 170 180 VAGVIARNPA LLDNLLSGGF LPIISSIAVD ENGLLMNVNA DQAATAIASL IDADLVMLSD 190 200 210 220 230 240 VDGVLDADKT LLSELNSAQI ARLIENKVIT DGMIVKVNAA LDAAKILNRG VDIANWKYPE 250 KLTALFAGEI IGTRIAP

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000746 Genomic DNA. Translation: ABR73633.1.
RefSeq	YP_001343568.1. NC_009655.1.
3D structure databases
ProteinModelPortal	A6VKY6.
SMR	A6VKY6. Positions 1-255.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VKY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5349300.
GenomeReviews	Gene locus Asuc_0254 in contig CP000746_GR.
KEGG	asu:Asuc_0254.
PATRIC	20758694. VBIActSuc117883_0277.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGCLVDD.
ProtClustDB	PRK00942.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ACTSZ

Accession

Primary (citable) accession number: A6VKY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program