A6VKY5 (ARLY_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Asuc_0253

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Argininosuccinate lyase HAMAP MF_00006		PRO_1000070918

Sequences

	Sequence		Length	Mass (Da)
	A6VKY5 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: B8DD2B2CEC8D7F10	FASTA	460	51,334
	10 20 30 40 50 60 MALWGGRFTQ AADKRFKDFN DSLRFDYRLA EQDIEGSIGW SKALVSVNIL TQDEQRQLEK 70 80 90 100 110 120 ALNELLIEVR SNPQAILQDD AEDIHSWVES KLIDKVGNLG KKLHTGRSRN DQVALDIKMW 130 140 150 160 170 180 CKAQVLELQK TVRELQAKLV LTAENTQHAV MPGYTHLQRA QPISFAHWCM AYVEMLERDY 190 200 210 220 230 240 TRLGDAYQRM NACPLGSGAL AGTAYPIDRE QLAQDLDFAS ATRNSLDSVS DRDHIIELLS 250 260 270 280 290 300 TASLSMAHLS RFAEDMIIFN SGEADFVELS DRVTSGSSLM PQKKNPDACE LIRGKTGRVI 310 320 330 340 350 360 GSLMGMLTTV KGLPLAYNKD MQEDKEGIFD ALDTWHDCLT MAAFVLEDIK VNVERTREAA 370 380 390 400 410 420 LKGYSNATEL ADYLVAKGVP FRDSHHIVGE TVVYAIKVHK GLEDLTVDEF RQFSDVVSDD 430 440 450 460 VYDILSLQSC LDKRCAKGGV SPLRVAEAIA DAKQRIGLNA

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000746 Genomic DNA. Translation: ABR73632.1.
RefSeq	YP_001343567.1. NC_009655.1.
3D structure databases
ProteinModelPortal	A6VKY5.
SMR	A6VKY5. Positions 3-457.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VKY5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5348185.
GenomeReviews	Gene locus Asuc_0253 in contig CP000746_GR.
KEGG	asu:Asuc_0253.
PATRIC	20758692. VBIActSuc117883_0276.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	MAEDLIF.
ProtClustDB	PRK04833.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ACTSZ

Accession

Primary (citable) accession number: A6VKY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program