Reviewed, UniProtKB/Swiss-Prot A6VKU4 (NAGZ_ACTSZ)

Names and origin

Protein names

Recommended name:
    Beta-hexosaminidase
    EC=3.2.1.52
Alternative name(s):
    N-acetyl-beta-glucosaminidase
    Beta-N-acetylhexosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	Asuc_0211

Organism

Actinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]

Taxonomic identifier

339671 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_00364
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Beta-hexosaminidase HAMAP MF_00364		PRO_1000072095
Sites
	Active site	249	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6VKU4-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 998C27E541C896B6	FASTA	346	38,882
	10 20 30 40 50 60 MSTLLIDLKG QTLRQEEVEL LEHPLVAGLI LFTRNFYDRP QIQALVKDIR QRVKKPLLIT 70 80 90 100 110 120 VDQEGGRVQR FRDGFTKLPA MQSFAALIQE PEQQLATAKE AGWQMAAEMT ALDIDLSFAP 130 140 150 160 170 180 VLDLGHECKA IGDRSFCSDA ESVFRLASAF IDGMHAAGMA TTGKHFPGHG HVLADSHLET 190 200 210 220 230 240 PFDNRPSAVI FERDIRPFQR LIAQNKLNAV MPAHVIYTDC DDQPASGSKY WLQDILRRKL 250 260 270 280 290 300 GFHGAVFSDD LGMKGAGFMG DFVTRSEKAL SAGCDLLLLC NEPDGVVQVL DNLKLNESRP 310 320 330 340 HFEARQQRLK TLFKKKSFNW TELTQTEKWL KNTQKLTALQ AQWQSS

References

[1]

"Complete sequence of Actinobacillus succinogenes 130Z." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000746 Genomic DNA. Translation: ABR73591.1.
RefSeq	YP_001343526.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VKU4.
Genome annotation databases
GeneID	5348752.
GenomeReviews	Gene locus Asuc_0211 in contig CP000746_GR.
KEGG	asu:Asuc_0211.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	AKEAGWQ.
Family and domain databases
HAMAP	MF_00364. [Tree]
InterPro	IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. [Graphical view]
Gene3D	G3DSA:3.20.20.300. Glyco_hydro_3_N. 1 hit.
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_ACTSZ

Accession

Primary (citable) accession number: A6VKU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)