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A6VKU4 (NAGZ_ACTSZ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:Asuc_0211
OrganismActinobacillus succinogenes (strain ATCC 55618 / 130Z) [Complete proteome] [HAMAP]
Taxonomic identifier339671 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_1000072095

Regions

Region164 – 1652Substrate binding By similarity

Sites

Active site1771Proton donor/acceptor By similarity
Active site2491Nucleophile By similarity
Binding site621Substrate By similarity
Binding site701Substrate By similarity
Binding site1341Substrate By similarity
Site1751Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A6VKU4 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 998C27E541C896B6

FASTA34638,882
        10         20         30         40         50         60 
MSTLLIDLKG QTLRQEEVEL LEHPLVAGLI LFTRNFYDRP QIQALVKDIR QRVKKPLLIT 

        70         80         90        100        110        120 
VDQEGGRVQR FRDGFTKLPA MQSFAALIQE PEQQLATAKE AGWQMAAEMT ALDIDLSFAP 

       130        140        150        160        170        180 
VLDLGHECKA IGDRSFCSDA ESVFRLASAF IDGMHAAGMA TTGKHFPGHG HVLADSHLET 

       190        200        210        220        230        240 
PFDNRPSAVI FERDIRPFQR LIAQNKLNAV MPAHVIYTDC DDQPASGSKY WLQDILRRKL 

       250        260        270        280        290        300 
GFHGAVFSDD LGMKGAGFMG DFVTRSEKAL SAGCDLLLLC NEPDGVVQVL DNLKLNESRP 

       310        320        330        340 
HFEARQQRLK TLFKKKSFNW TELTQTEKWL KNTQKLTALQ AQWQSS 

« Hide

References

[1]"Complete sequence of Actinobacillus succinogenes 130Z."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 55618 / 130Z.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000746 Genomic DNA. Translation: ABR73591.1.
RefSeqYP_001343526.1. NC_009655.1.

3D structure databases

ProteinModelPortalA6VKU4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING339671.Asuc_0211.

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR73591; ABR73591; Asuc_0211.
GeneID5348752.
KEGGasu:Asuc_0211.
PATRIC20758602. VBIActSuc117883_0231.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000248526.
KOK01207.
OMAAGFSSYW.
OrthoDBEOG6BCT06.
ProtClustDBPRK05337.

Enzyme and pathway databases

BioCycASUC339671:GHDX-223-MONOMER.
UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNAGZ_ACTSZ
AccessionPrimary (citable) accession number: A6VKU4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries