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Protein

UDP-N-acetyl-D-mannosamine dehydrogenase

Gene

wecC

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD+ and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei261By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 28NADSequence analysisAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetyl-D-mannosamine dehydrogenase (EC:1.1.1.336)
Alternative name(s):
UDP-ManNAc 6-dehydrogenase
Gene namesi
Name:wecC
Ordered Locus Names:MmarC7_1733
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000002298 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003378381 – 427UDP-N-acetyl-D-mannosamine dehydrogenaseAdd BLAST427

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi426368.MmarC7_1733.

Structurei

3D structure databases

ProteinModelPortaliA6VK13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00252. Archaea.
COG0677. LUCA.
HOGENOMiHOG000153774.
KOiK02472.
OMAiREMMATE.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028359. UDP_ManNAc/GlcNAc_DH.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500136. UDP_ManNAc_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

A6VK13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKHGNYDIK KICVIGLGYI GLPTASMLAN HGYEVVGVDV NEKRVNHIKN
60 70 80 90 100
GELKIEEPGL LTLVKGAINS KNLNVQTSAE EADAFIICVP TPALENEDGS
110 120 130 140 150
KKCDLTYVMS AVQAIIPFLK DGNLIVVEST IPPETTKKIY ETINKKIYVA
160 170 180 190 200
HCPERVLPGK ILKELVENDR IIGGINKKSA EMAKEIYKSF VEGKIYITDS
210 220 230 240 250
NTAEMVKLME NTYRDINIAL ANEFAKICDE IGVNVWDAIK IANKHPRVNI
260 270 280 290 300
LNPGPGVGGH CISIDPWFIV EKTNNAKFIR AARELNDNMP AYVCKSVLSE
310 320 330 340 350
LNKLGIEKPK ISIFGATYKG NVEDTRESPS KNVIKMLLEN GATVSTFDPH
360 370 380 390 400
ADCFEYPLST LDECISGSDC IVVLTDHDAF KNIKKDDIDE ICPKLKNKIV
410 420
FDTKNILEHN LWKKAGFKVK LLGNGAW
Length:427
Mass (Da):47,334
Last modified:August 21, 2007 - v1
Checksum:i24EC219F25D7C307
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR66789.1.
RefSeqiWP_012068249.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR66789; ABR66789; MmarC7_1733.
GeneIDi5328535.
KEGGimmz:MmarC7_1733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR66789.1.
RefSeqiWP_012068249.1. NC_009637.1.

3D structure databases

ProteinModelPortaliA6VK13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426368.MmarC7_1733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR66789; ABR66789; MmarC7_1733.
GeneIDi5328535.
KEGGimmz:MmarC7_1733.

Phylogenomic databases

eggNOGiarCOG00252. Archaea.
COG0677. LUCA.
HOGENOMiHOG000153774.
KOiK02472.
OMAiREMMATE.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028359. UDP_ManNAc/GlcNAc_DH.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500136. UDP_ManNAc_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWECC_METM7
AccessioniPrimary (citable) accession number: A6VK13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.