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A6VK04 (SYL_METM7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:MmarC7_1724
OrganismMethanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]
Taxonomic identifier426368 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length955 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 955955Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334845

Regions

Motif51 – 6111"HIGH" region HAMAP-Rule MF_00049
Motif647 – 6515"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6501ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6VK04 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: A3B04A5568BD769D

FASTA955110,812
        10         20         30         40         50         60 
MDQNGVNAGN GHKSIDLIQI MDKWQKKWTE AKIFEAEHDL RDKFFITAAF PYLNGVLHAG 

        70         80         90        100        110        120 
HLRTFTIPET IARYQRMKNK NVLWTFGFHV TGTPILGLAN QIKERKEDII WAYNNLHNIP 

       130        140        150        160        170        180 
MDELIKLDTP EAIVECFSKK ATEAFKRMGF SLDWRRNFKT DDKVFSKFIE WQFYKLKEMG 

       190        200        210        220        230        240 
HITKGSHPVR YCPKCENPVE DHDLLHGEES TTVEYSLIKF TSEFDGKEII MPMATLRPET 

       250        260        270        280        290        300 
LFGVTNAWVN PNEMYVMAEV YDEIQKLDSE DVDLKYNGIW IVGKECADKL KEQDRKIEIL 

       310        320        330        340        350        360 
KEIKGSELLG LKIKNPVTKK EVPLFPADFV EMGIGTGCVM GVPAHAPYDY IALRDLGKIE 

       370        380        390        400        410        420 
EVGLIPLIEI EGYDKFPAKE IVEKLGVKDQ NDDELLEQAT SKIYKDEFHK GKLNENCGEY 

       430        440        450        460        470        480 
AGISVKDIKE KLTKDYLNSN IAEIMYEFSE QKVVCRCGEK CIIKTVKGQW FINYSDENWK 

       490        500        510        520        530        540 
KLAHECIDSM NFAPENIRQE FHNKVDWMKD KACARKKGLG TLLPFDENWI IESLSDSTIY 

       550        560        570        580        590        600 
MAYYTIARFI NEGLTPEQLV PELFEYVFLG NGNVEEIAKN SNISKETIEE MRKEFLYYYP 

       610        620        630        640        650        660 
LDWRCSAKDL IPNHLTFMIF NHVALFKKEH WPRGIEINGY VTIEGKKLSK SKGPVLPVSE 

       670        680        690        700        710        720 
VAENFGADVA RFYITTCAEL PQDADVKFKE MEKARDNLIK LYELAVSVME EESTQKEFSL 

       730        740        750        760        770        780 
IDKWLLHKTY SSIKGAETAY EEFQLRKIGL MFYELINDLR WYKRRGGENN NVLKEVVEIW 

       790        800        810        820        830        840 
TKLLSPVTPH LCEEIWEKLG YSGFISQEMY PEIKSELINE DLELGEEFIK SAMEDIRNIK 

       850        860        870        880        890        900 
GVAKINPEKM YLYTADDWKY DLLEFMNENS EKNVKAIIPL VMKEDKFKRH GKEVMKLINE 

       910        920        930        940        950 
IMKIGVKKAI AEVEILENAK TFIESEFDCE VIVNGEDVKG KKKFAIPYKP AIYME 

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References

[1]"Complete sequence of Methanococcus maripaludis C7."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C7 / ATCC BAA-1331.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000745 Genomic DNA. Translation: ABR66780.1.
RefSeqYP_001330931.1. NC_009637.1.

3D structure databases

ProteinModelPortalA6VK04.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING426368.MmarC7_1724.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR66780; ABR66780; MmarC7_1724.
GeneID5328316.
KEGGmmz:MmarC7_1724.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000216620.
KOK01869.
OMAIDKWLLH.

Enzyme and pathway databases

BioCycMMAR426368:GHHL-1770-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_A. Leu_tRNA_synth_A.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_METM7
AccessionPrimary (citable) accession number: A6VK04
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries