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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei650 – 6501ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-1770-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MmarC7_1724
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000002298: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Leucine--tRNA ligasePRO_0000334845Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_1724.

Structurei

3D structure databases

ProteinModelPortaliA6VK04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionAdd
BLAST
Motifi647 – 6515"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiYEGVMLV.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VK04-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQNGVNAGN GHKSIDLIQI MDKWQKKWTE AKIFEAEHDL RDKFFITAAF
60 70 80 90 100
PYLNGVLHAG HLRTFTIPET IARYQRMKNK NVLWTFGFHV TGTPILGLAN
110 120 130 140 150
QIKERKEDII WAYNNLHNIP MDELIKLDTP EAIVECFSKK ATEAFKRMGF
160 170 180 190 200
SLDWRRNFKT DDKVFSKFIE WQFYKLKEMG HITKGSHPVR YCPKCENPVE
210 220 230 240 250
DHDLLHGEES TTVEYSLIKF TSEFDGKEII MPMATLRPET LFGVTNAWVN
260 270 280 290 300
PNEMYVMAEV YDEIQKLDSE DVDLKYNGIW IVGKECADKL KEQDRKIEIL
310 320 330 340 350
KEIKGSELLG LKIKNPVTKK EVPLFPADFV EMGIGTGCVM GVPAHAPYDY
360 370 380 390 400
IALRDLGKIE EVGLIPLIEI EGYDKFPAKE IVEKLGVKDQ NDDELLEQAT
410 420 430 440 450
SKIYKDEFHK GKLNENCGEY AGISVKDIKE KLTKDYLNSN IAEIMYEFSE
460 470 480 490 500
QKVVCRCGEK CIIKTVKGQW FINYSDENWK KLAHECIDSM NFAPENIRQE
510 520 530 540 550
FHNKVDWMKD KACARKKGLG TLLPFDENWI IESLSDSTIY MAYYTIARFI
560 570 580 590 600
NEGLTPEQLV PELFEYVFLG NGNVEEIAKN SNISKETIEE MRKEFLYYYP
610 620 630 640 650
LDWRCSAKDL IPNHLTFMIF NHVALFKKEH WPRGIEINGY VTIEGKKLSK
660 670 680 690 700
SKGPVLPVSE VAENFGADVA RFYITTCAEL PQDADVKFKE MEKARDNLIK
710 720 730 740 750
LYELAVSVME EESTQKEFSL IDKWLLHKTY SSIKGAETAY EEFQLRKIGL
760 770 780 790 800
MFYELINDLR WYKRRGGENN NVLKEVVEIW TKLLSPVTPH LCEEIWEKLG
810 820 830 840 850
YSGFISQEMY PEIKSELINE DLELGEEFIK SAMEDIRNIK GVAKINPEKM
860 870 880 890 900
YLYTADDWKY DLLEFMNENS EKNVKAIIPL VMKEDKFKRH GKEVMKLINE
910 920 930 940 950
IMKIGVKKAI AEVEILENAK TFIESEFDCE VIVNGEDVKG KKKFAIPYKP

AIYME
Length:955
Mass (Da):110,812
Last modified:August 21, 2007 - v1
Checksum:iA3B04A5568BD769D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR66780.1.
RefSeqiYP_001330931.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR66780; ABR66780; MmarC7_1724.
GeneIDi5328316.
KEGGimmz:MmarC7_1724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR66780.1.
RefSeqiYP_001330931.1. NC_009637.1.

3D structure databases

ProteinModelPortaliA6VK04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426368.MmarC7_1724.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR66780; ABR66780; MmarC7_1724.
GeneIDi5328316.
KEGGimmz:MmarC7_1724.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiYEGVMLV.

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-1770-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C7 / ATCC BAA-1331.

Entry informationi

Entry nameiSYL_METM7
AccessioniPrimary (citable) accession number: A6VK04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: January 7, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.