Reviewed, UniProtKB/Swiss-Prot A6VJW6 (APT2_METM7)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase 2
      Short name=APRT 2
    EC=2.4.2.7

Gene names

Name:	apt2
Ordered Locus Names:	MmarC7_1686

Organism

Methanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]

Taxonomic identifier

426368 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Adenine phosphoribosyltransferase 2 HAMAP MF_00004		PRO_0000329376

Sequences

	Sequence		Length	Mass (Da)
	A6VJW6-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: E81AC537F0F415C3	FASTA	172	19,067
	10 20 30 40 50 60 MDLRKKIRIV EDFPIKGISF KDVTPILKDP KAMKHTTKEI TKYLEDKNID IIVGPEARGF 70 80 90 100 110 120 LFGVPVAHEL DIGFVPVRKP GKLPFKTFSV DYALEYGTDK LEIHSDGIEK GQNVAIVDDL 130 140 150 160 170 LATGGTVSGV SKLVEKIGGH VSALNFVIEL TELKGRDKLK GYDIQSLVKY DL

References

[1]

"Complete sequence of Methanococcus maripaludis C7." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000745 Genomic DNA. Translation: ABR66742.1.
RefSeq	YP_001330893.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6VJW6.
Genome annotation databases
GeneID	5329107.
GenomeReviews	Gene locus MmarC7_1686 in contig CP000745_GR.
KEGG	mmz:MmarC7_1686.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KPGKLPA.
Family and domain databases
HAMAP	MF_00004. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT2_METM7

Accession

Primary (citable) accession number: A6VJW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	August 21, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)