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A6VJV1

- A6VJV1_METM7

UniProt

A6VJV1 - A6VJV1_METM7

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei92 – 921SubstrateUniRule annotation
Binding sitei99 – 991NADUniRule annotation
Binding sitei123 – 1231SubstrateUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Active sitei178 – 1781Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 137NADUniRule annotation
Nucleotide bindingi121 – 1233NADUniRule annotation

GO - Molecular functioni

  1. L-lactate dehydrogenase activity Source: InterPro
  2. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-1715-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:MmarC7_1669Imported
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)Imported
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000002298: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_1669.

Structurei

3D structure databases

ProteinModelPortaliA6VJV1.
SMRiA6VJV1. Positions 1-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYAPSAFV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VJV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVSIIGASG KIGSVLSLLL AKESYIKNIN LIARNGSINK LKGLKMDLYD
60 70 80 90 100
AMAAAGQDTN IQICSDDDLS CTGTSDITIV TAGMARTGDM SRIDLMRENA
110 120 130 140 150
KIIKNYAKKI ANAGDTKIFM ISNPVDMMTY KAFIESGYEK NQVFGLGTHL
160 170 180 190 200
DSMRFKVAVA KYFEVHIDDV RTRIVGEHGD SMVPLISATA VGGIPIVRLP
210 220 230 240 250
KYENFPYDRI LEKIKGYGKE IIDLKNGSEY GPASAIVNIV RCIAHDEKRL
260 270 280 290 300
LTLSAYIEDE IEGIKGGSCI GVPVKVGKNG IEEVIHMKMN DDEIEGFKKS
310
FDLVKGYCKE IESI
Length:314
Mass (Da):34,434
Last modified:August 21, 2007 - v1
Checksum:iF71F3DB39CB0CEE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR66727.1.
RefSeqiWP_012068187.1. NC_009637.1.
YP_001330878.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR66727; ABR66727; MmarC7_1669.
GeneIDi5328831.
KEGGimmz:MmarC7_1669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR66727.1 .
RefSeqi WP_012068187.1. NC_009637.1.
YP_001330878.1. NC_009637.1.

3D structure databases

ProteinModelPortali A6VJV1.
SMRi A6VJV1. Positions 1-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426368.MmarC7_1669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR66727 ; ABR66727 ; MmarC7_1669 .
GeneIDi 5328831.
KEGGi mmz:MmarC7_1669.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YAPSAFV.

Enzyme and pathway databases

BioCyci MMAR426368:GHHL-1715-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
PROSITEi PS00064. L_LDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C7 / ATCC BAA-1331Imported.

Entry informationi

Entry nameiA6VJV1_METM7
AccessioniPrimary (citable) accession number: A6VJV1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3