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A6VJV1

- A6VJV1_METM7

UniProt

A6VJV1 - A6VJV1_METM7

Protein

Malate dehydrogenase

Gene

mdh

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861SubstrateUniRule annotation
    Binding sitei92 – 921SubstrateUniRule annotation
    Binding sitei99 – 991NADUniRule annotation
    Binding sitei123 – 1231SubstrateUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Active sitei178 – 1781Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 137NADUniRule annotation
    Nucleotide bindingi121 – 1233NADUniRule annotation

    GO - Molecular functioni

    1. L-lactate dehydrogenase activity Source: InterPro
    2. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    NADUniRule annotation

    Enzyme and pathway databases

    BioCyciMMAR426368:GHHL-1715-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:MmarC7_1669Imported
    OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)Imported
    Taxonomic identifieri426368 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000002298: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi426368.MmarC7_1669.

    Structurei

    3D structure databases

    ProteinModelPortaliA6VJV1.
    SMRiA6VJV1. Positions 1-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYAPSAFV.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR018177. L-lactate_DH_AS.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    PROSITEiPS00064. L_LDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6VJV1-1 [UniParc]FASTAAdd to Basket

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    MEVSIIGASG KIGSVLSLLL AKESYIKNIN LIARNGSINK LKGLKMDLYD    50
    AMAAAGQDTN IQICSDDDLS CTGTSDITIV TAGMARTGDM SRIDLMRENA 100
    KIIKNYAKKI ANAGDTKIFM ISNPVDMMTY KAFIESGYEK NQVFGLGTHL 150
    DSMRFKVAVA KYFEVHIDDV RTRIVGEHGD SMVPLISATA VGGIPIVRLP 200
    KYENFPYDRI LEKIKGYGKE IIDLKNGSEY GPASAIVNIV RCIAHDEKRL 250
    LTLSAYIEDE IEGIKGGSCI GVPVKVGKNG IEEVIHMKMN DDEIEGFKKS 300
    FDLVKGYCKE IESI 314
    Length:314
    Mass (Da):34,434
    Last modified:August 21, 2007 - v1
    Checksum:iF71F3DB39CB0CEE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000745 Genomic DNA. Translation: ABR66727.1.
    RefSeqiYP_001330878.1. NC_009637.1.

    Genome annotation databases

    EnsemblBacteriaiABR66727; ABR66727; MmarC7_1669.
    GeneIDi5328831.
    KEGGimmz:MmarC7_1669.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000745 Genomic DNA. Translation: ABR66727.1 .
    RefSeqi YP_001330878.1. NC_009637.1.

    3D structure databases

    ProteinModelPortali A6VJV1.
    SMRi A6VJV1. Positions 1-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426368.MmarC7_1669.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR66727 ; ABR66727 ; MmarC7_1669 .
    GeneIDi 5328831.
    KEGGi mmz:MmarC7_1669.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YAPSAFV.

    Enzyme and pathway databases

    BioCyci MMAR426368:GHHL-1715-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR018177. L-lactate_DH_AS.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    PROSITEi PS00064. L_LDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C7 / ATCC BAA-1331Imported.

    Entry informationi

    Entry nameiA6VJV1_METM7
    AccessioniPrimary (citable) accession number: A6VJV1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3