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Protein

Shikimate kinase

Gene

aroK

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 3-dehydroquinate dehydratase (aroD)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. no protein annotated in this organism
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 96ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR426368:G1G9C-1367-MONOMER
UniPathwayiUPA00053; UER00088

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:MmarC7_1322
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000002298 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000599351 – 283Shikimate kinaseAdd BLAST283

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_1322

Structurei

3D structure databases

ProteinModelPortaliA6VIV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01025 Archaea
COG1685 LUCA
HOGENOMiHOG000105526
KOiK00891
OMAiDATASYY
OrthoDBiPOG093Z0EB9

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
HAMAPiMF_00370 Shik_kinase_arch, 1 hit
InterProiView protein in InterPro
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR010189 SK_arc
PANTHERiPTHR20861:SF3 PTHR20861:SF3, 1 hit
PfamiView protein in Pfam
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF005758 Shikimt_kin_arch, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR01920 Shik_kin_archae, 1 hit

Sequencei

Sequence statusi: Complete.

A6VIV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCSAVSLGS GTIINAIATG FGSAFGVDLK IKADVELLDN GKKIINGISI
60 70 80 90 100
DNPTLKPSLV ERCVKNVLDY FEVDYSAKIS TSGDIPVKSG LSSSSAASNA
110 120 130 140 150
AVLATIGALG EKVDSDLVLD LAIKSSFEEK LTVTGAYDDA TASYFGGITV
160 170 180 190 200
CNNMERKILK KDEFKEDIKV VVLMPEFQKN VDVKRMKLIK DYVDMAFEKC
210 220 230 240 250
MAGDYYKALF LNGLLYSSAL NFPSNISVDA LEAGAITAGL SGTGPSYVAL
260 270 280
CYNENEKNVE NALKKYGNTV ITKPCINGAR ILY
Length:283
Mass (Da):30,330
Last modified:August 21, 2007 - v1
Checksum:i6AC4FB5B41D44C73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA Translation: ABR66385.1
RefSeqiWP_012067852.1, NC_009637.1

Genome annotation databases

EnsemblBacteriaiABR66385; ABR66385; MmarC7_1322
GeneIDi5329467
KEGGimmz:MmarC7_1322

Similar proteinsi

Entry informationi

Entry nameiAROK_METM7
AccessioniPrimary (citable) accession number: A6VIV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health