A6VID5 (APT1_METM7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase 1
Short name=APRT 1
EC=2.4.2.7

Gene names

Name:	apt1
Ordered Locus Names:	MmarC7_1145

Organism

Methanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]

Taxonomic identifier

426368 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity. HAMAP MF_00004
Subcellular location	Cytoplasm By similarity HAMAP MF_00004.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Adenine phosphoribosyltransferase 1 HAMAP MF_00004		PRO_0000329375

Sequences

	Sequence		Length	Mass (Da)
	A6VID5 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 19665ACE7685686C	FASTA	185	20,429
	10 20 30 40 50 60 MSRLLEESLK TCPIVKRGEY HYFIHPISDG VPLVKPELLR DVSTRVIKMI DTDIDKIVTA 70 80 90 100 110 120 EAMGIPIVTA VSIATDIPYV IMRKREYLLE GEIPVHQETG YSKGELYLNG INKGDKVVIL 130 140 150 160 170 180 DDVISTGGTL VAIINALKRA GADIKDVLCI IDRGNGQNVV EEKTGYKVKT LVKIEVVDGK VQILE

References

[1]

"Complete sequence of Methanococcus maripaludis C7." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C7 / ATCC BAA-1331.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000745 Genomic DNA. Translation: ABR66211.1.
RefSeq	YP_001330362.1. NC_009637.1.
3D structure databases
ProteinModelPortal	A6VID5.
ModBase	Search...
Protein-protein interaction databases
STRING	A6VID5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5328744.
GenomeReviews	Gene locus MmarC7_1145 in contig CP000745_GR.
KEGG	mmz:MmarC7_1145.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05998.
HOGENOM	HBG496859.
OMA	NYFIHPI.
ProtClustDB	PRK02304.
Enzyme and pathway databases
BioCyc	MMAR426368:MMARC7_1145-MONOMER.
Family and domain databases
HAMAP	MF_00004. Aden_phosphoribosyltr. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
KO	K00759.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT1_METM7

Accession

Primary (citable) accession number: A6VID5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program