A6VIC0 (MFNA_METM7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-tyrosine decarboxylase
Short name=TDC
EC=4.1.1.25

Gene names

Name:	mfnA
Ordered Locus Names:	MmarC7_1130

Organism

Methanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]

Taxonomic identifier

426368 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus maripaludis

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine By similarity. HAMAP-Rule MF_01610
Catalytic activity	L-tyrosine = tyramine + CO2. HAMAP-Rule MF_01610
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_01610
Pathway	Cofactor biosynthesis; methanofuran biosynthesis. HAMAP-Rule MF_01610
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01610
Sequence similarities	Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	coenzyme biosynthetic process Inferred from electronic annotation. Source: HAMAP tyrosine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP tyrosine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	L-tyrosine decarboxylase HAMAP-Rule MF_01610		PRO_1000069445
Amino acid modifications
	Modified residue	233	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6VIC0 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 36275821C15D6329	FASTA	384	43,320
	10 20 30 40 50 60 MDEQDILKEL RKYRSQDLKY EEGYILGSMC TKPHPMARKI SEMFFETNLG DPGLFKGTSK 70 80 90 100 110 120 LEKEVVSMLG GILHNNNAFG YIISGGTEAN LTAMRAFKNI SKSKDKQQNI IIPETAHFSF 130 140 150 160 170 180 DKARDMMDLN VVRPPLTEYF TMDVKFIRDY IEDSKNEISG IVGIAGCTEL GSIDNIYELS 190 200 210 220 230 240 KIAVENDILL HVDAAFGGFV IPFLDDKYKL KGYNYDFDFS LNGVSSITID PHKMGLAPIS 250 260 270 280 290 300 AGGILFKNNT FKNYLDVDAP YLTEKQQATL IGTRSGVGVA STWGIMKLLG IDGYKKLVNE 310 320 330 340 350 360 SMEKTMHLVK KAREYGFETA IDPVMNIVAL KDEDKHDTCM KLREENWYVS VCRCVEALRI 370 380 VVMPHLEIEH IDGFLESLSN TKKY

References

[1]

"Complete sequence of Methanococcus maripaludis C7." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C7 / ATCC BAA-1331.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000745 Genomic DNA. Translation: ABR66196.1.
RefSeq	YP_001330347.1. NC_009637.1.
3D structure databases
ProteinModelPortal	A6VIC0.
ModBase	Search...
Protein-protein interaction databases
STRING	426368.MmarC7_1130.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR66196; ABR66196; MmarC7_1130.
GeneID	5328640.
KEGG	mmz:MmarC7_1130.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0076.
HOGENOM	HOG000246269.
KO	K01592.
OMA	DAPYLTE.
ProtClustDB	PRK13520.
Enzyme and pathway databases
BioCyc	MMAR426368:GHHL-1169-MONOMER.
UniPathway	UPA00080.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_01610. Tyr_decarbox.
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR021115. Pyridoxal-P_BS. IPR020931. Tyr_deCO2ase. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MFNA_METM7

Accession

Primary (citable) accession number: A6VIC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	May 29, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program