A6VIA5 (ARGC_METM7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	MmarC7_1115

Organism

Methanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]

Taxonomic identifier

426368 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus maripaludis

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP-Rule MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP-Rule MF_00150
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP-Rule MF_00150		PRO_1000011013
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6VIA5 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: C51A730691B92505	FASTA	343	37,937
	10 20 30 40 50 60 MKTVSIIGGT GYTGSELLRL LSTHEKVEVL NVTSRKEAGK KLTDFHPQVR NLRNYNDLEF 70 80 90 100 110 120 QNIAPEDIDT DIVFCATPHG ASMAIVPILH EKGINIIDLS GDYRFEDIEM YESWYGLKHT 130 140 150 160 170 180 GKIESAVYGL PELHREKIKK SKTIANPGCY PTGAILSMAP LVANDLVDER IIFDSKSGVS 190 200 210 220 230 240 GAGVEASQTT HFPNVNENLG AYKITKHRHS PEIGKELEYL GNKKLKVSFT PHLLPVTRGI 250 260 270 280 290 300 LTTAHSYLKE DVSRADVIEI YEEFYDGEFF VRIFEEGMVS LTGVRGTNFC DIGGFEIDQH 310 320 330 340 GRIVVVSAID NLVKGASGQA IQNMNIIMGF DEKMGLSVGG MRP

References

[1]

"Complete sequence of Methanococcus maripaludis C7." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C7 / ATCC BAA-1331.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000745 Genomic DNA. Translation: ABR66181.1.
RefSeq	YP_001330332.1. NC_009637.1.
3D structure databases
ProteinModelPortal	A6VIA5.
ModBase	Search...
Protein-protein interaction databases
STRING	426368.MmarC7_1115.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABR66181; ABR66181; MmarC7_1115.
GeneID	5328432.
KEGG	mmz:MmarC7_1115.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HOG000254902.
KO	K00145.
OMA	VCRIAVH.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	MMAR426368:GHHL-1154-MONOMER.
UniPathway	UPA00068; UER00108.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_00150. ArgC_type1.
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_METM7

Accession

Primary (citable) accession number: A6VIA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	May 29, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program