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A6VI22 (MPTA_METM7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase MptA
EC=3.5.4.n2
Gene names
Name:mptA
Ordered Locus Names:MmarC7_1031
OrganismMethanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]
Taxonomic identifier426368 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus ›

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate. HAMAP-Rule MF_01527

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Pathway

Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. HAMAP-Rule MF_01527

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionGTP cyclohydrolase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315GTP cyclohydrolase MptA HAMAP-Rule MF_01527
PRO_1000068667

Sites

Site1611May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A6VI22 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 1B8F16ED72272D84

FASTA31535,702
        10         20         30         40         50         60 
MQCNDVQATE PDIKVSLTRV GVTNLKKLVK LKRTNKRDIV LLPTFEVFVD LPSSQKGIHM 

        70         80         90        100        110        120 
SRSPEVIEEV VENILLEKEI YGVEDLSVEI VMKLFEKHEY ATRAEVMLYS DYMMEETSPV 

       130        140        150        160        170        180 
TQKDSQEIAK IMARAYGVKD DCGKIHVKKM VGAEVVGITA CPCAQNMLKE NAVTSLKEKG 

       190        200        210        220        230        240 
FSSEDIEKIL DSVTIATHNQ RGIGTVMIEV PSGYTVGISK IIKIIKDSMS GEVYELLKRS 

       250        260        270        280        290        300 
DEAYVVEMAH KNPKFVEDCA REMIKRVVDV FDYLPEDTQV LVRQVNKESI HRHDAFAERN 

       310 
STIRELRDEL KTLTN

« Hide

References

[1]"Complete sequence of Methanococcus maripaludis C7."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C7 / ATCC BAA-1331.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000745 Genomic DNA. Translation: ABR66098.1.
RefSeqYP_001330249.1. NC_009637.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING426368.MmarC7_1031.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR66098; ABR66098; MmarC7_1031.
GeneID5329167.
KEGGmmz:MmarC7_1031.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280680.
KOK09007.
OMAVEDCVRE.
ProtClustDBPRK13675.

Enzyme and pathway databases

BioCycMMAR426368:GHHL-1078-MONOMER.
UniPathwayUPA00065.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
HAMAPMF_01527_A. GTP_cyclohydrol_A.
InterProIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPTA_METM7
AccessionPrimary (citable) accession number: A6VI22
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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