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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyciMMAR426368:MMARC7_RS05245-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Alternative name(s):
Exodeoxyribonuclease large subunitUniRule annotation (EC:3.1.11.1UniRule annotation)
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:MmarC7_1023
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000002298 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000193901 – 1131DNA polymerase II large subunitAdd BLAST1131

Proteomic databases

PRIDEiA6VI14

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi426368.MmarC7_1023

Structurei

3D structure databases

SMRiA6VI14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447 Archaea
COG1933 LUCA
HOGENOMiHOG000286435
KOiK02322
OMAiKRRNCDG
OrthoDBiPOG093Z06CT

Family and domain databases

HAMAPiMF_00324 DNApol_II_L_arch, 1 hit
InterProiView protein in InterPro
IPR004475 PolC_DP2
IPR016033 PolC_DP2_N
PANTHERiPTHR42210 PTHR42210, 3 hits
PfamiView protein in Pfam
PF03833 PolC_DP2, 1 hit
PIRSFiPIRSF016275 PolC_DP2, 1 hit
TIGRFAMsiTIGR00354 polC, 1 hit

Sequencei

Sequence statusi: Complete.

A6VI14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHVSASKGM TEYFKNILDN VTELYTLADD CRKSGYDVTD HVEIPLAKDM
60 70 80 90 100
ADRVEGIVGP KNVAERIREL VSDLGKEPAA LEIAKEIVEG KFGEFGREVG
110 120 130 140 150
AEQAVRTALA VITEGIVAAP LEGIAHVKIK KNNDSGEYLA IYFAGPIRSA
160 170 180 190 200
GGTAQALAVL VGDYVRKNMG LDKFKPTEDE VERYGEEVDL YQSEVTTFQY
210 220 230 240 250
QPKAEEIRAA VRNISVEITG EATDDVEVSG HRDLPRVETN QIRGGALLAL
260 270 280 290 300
VEGVLLKAPK ILRHVDKLGI EGWDWLKELK SKKEEVIEEI EEEKDDFNYE
310 320 330 340 350
EEEDLSQYED YEVEAVTKFI GEVIAGRPVF SHPSKKGGFR LRYGRSRNTG
360 370 380 390 400
FATDGFHPAI MYLVDDFMAV GTQLKTERPG KATCVVPVDS IEGPIVRLKD
410 420 430 440 450
KSVLKIDTVE KAKQYRDDVE EILFLGDILV NYGDFLENNH TILPSSWCTE
460 470 480 490 500
WYEKILKSEN LEYKKEFIEN PDQKEAVNYA KLTKTPLHPK YTYFWHDISK
510 520 530 540 550
DNINVLRNWI IGGKYNESND SWEVTYDSEN PEISNAKRYL ELIGCPHTVT
560 570 580 590 600
GEKLEIFEYY PLLYSLGYDF DEKRDIVEEI EEKLQNTKNN MHFINTIAPF
610 620 630 640 650
EIRRNAYIYV GARMGRPEKA ASRKMKPPVN GLFPIGNAGA LVRLINKAVE
660 670 680 690 700
EGKTDEIEIS NVKCSCGNVS LYRTCPFCGN SVEPSGPSRI KLPIKEYWYK
710 720 730 740 750
ALENLKINKA GDVKCIKGMT SKDKIIEPLE KAILRAKNDI YVFKDGTTRF
760 770 780 790 800
DCTDVPVTHF RPVEIHVGIE KLKSLGYLKD IHGNSLENED QVLELKVQDV
810 820 830 840 850
IVPESCMDYF FNVSKFIDDL LEKYYKKDRF YNVNKRDDLV GHLIIGMAPH
860 870 880 890 900
TSAGMVGRII GYSNANVGYA HPYFHASKRR NCDGDEDAFF LLLDAFMNFS
910 920 930 940 950
KRFLPDKRGG QMDAPLVLTT ILDPKEVDGE VHNMDSMWEY PIEFYEKSLE
960 970 980 990 1000
GIAPKEIKKI MQTVEDRLDK DSQYEGIGYT HETLKIDEGP LVCAYKTLGS
1010 1020 1030 1040 1050
MMEKTSAQLA VAKKIRATDE RDVAEKVIQS HFVPDLIGNL RAFSRQGVRC
1060 1070 1080 1090 1100
KCGAKYRRMP LKGVCRKCGS RLILTVSKGA VEKYMDVSQT MAEKYEASDY
1110 1120 1130
IKQRLEIIRS GIDSLFVNDK RKQVKIEDFF K
Length:1,131
Mass (Da):128,380
Last modified:August 21, 2007 - v1
Checksum:i143EE34A3D4BE0B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA Translation: ABR66090.1
RefSeqiWP_011977403.1, NC_009637.1

Genome annotation databases

EnsemblBacteriaiABR66090; ABR66090; MmarC7_1023
GeneIDi5329159
KEGGimmz:MmarC7_1023

Similar proteinsi

Entry informationi

Entry nameiDP2L_METM7
AccessioniPrimary (citable) accession number: A6VI14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: June 20, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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