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A6VHK3 (SYH_METM7) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase

EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:MmarC7_0862
OrganismMethanococcus maripaludis (strain C7 / ATCC BAA-1331) [Complete proteome] [HAMAP]
Taxonomic identifier426368 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: InterPro

histidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Histidine--tRNA ligase HAMAP-Rule MF_00127
PRO_1000016392

Sequences

Sequence LengthMass (Da)Tools
A6VHK3 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 05EA8EC382B5BD7E

FASTA41847,849
        10         20         30         40         50         60 
MIMFQKPKGT RDFLPEEMKK RKVIEKKLRK VFDSYNFSEI NTPTFESFEL LSKKTGDEIR 

        70         80         90        100        110        120 
TQLFVFKDHG DREMGLRPEL TSSVARFYIN EFKNTPKPVK LYYFTNCFRY ENPQAGRYRE 

       130        140        150        160        170        180 
FWQMGSELIG SNKPIADAEV INMAIEGLKE INMDFEINIG HLGVLKGVFE KYDLSDDEGN 

       190        200        210        220        230        240 
EIRRLIDKED MDGLKSALNR IESEKNIEIS EKVFEVLDLK GGREVISKLK EKLAEFESSI 

       250        260        270        280        290        300 
AALENLDSIL EFVPHEYIIN FGIARGLDYY TGMVFEIYGK REGARQVCGG GRYDNLIELF 

       310        320        330        340        350        360 
EGEPSPAVGF AYGFDRIMLN IDDFEVEEES IFVVPVKSSD MLLNECLKIA KTLREAGKAV 

       370        380        390        400        410 
ELDLMGRKLN KALNYANTKG IKKVIIVGEN DILEGKVALK NMETGEQSLI ELKDILTI 

« Hide

References

[1]"Complete sequence of Methanococcus maripaludis C7."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C7 / ATCC BAA-1331.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000745 Genomic DNA. Translation: ABR65929.1.
RefSeqYP_001330080.1. NC_009637.1.

3D structure databases

ProteinModelPortalA6VHK3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING426368.MmarC7_0862.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR65929; ABR65929; MmarC7_0862.
GeneID5329373.
KEGGmmz:MmarC7_0862.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
HOGENOMHOG000018073.
KOK01892.
OMAFENCFRY.
ProtClustDBPRK00037.

Enzyme and pathway databases

BioCycMMAR426368:GHHL-875-MONOMER.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00125. HisZ.
MF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisRS/HisZ_bac.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. SSF52954. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
TIGR00443. hisZ_biosyn_reg. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_METM7
AccessionPrimary (citable) accession number: A6VHK3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries