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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. histidine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: InterPro
  2. histidyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:MmarC7_0862
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000002298 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Histidine--tRNA ligasePRO_1000016392Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_0862.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018073.
KOiK01892.
OMAiNMFRYEE.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00125. HisZ.
MF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
TIGR00443. hisZ_biosyn_reg. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VHK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMFQKPKGT RDFLPEEMKK RKVIEKKLRK VFDSYNFSEI NTPTFESFEL
60 70 80 90 100
LSKKTGDEIR TQLFVFKDHG DREMGLRPEL TSSVARFYIN EFKNTPKPVK
110 120 130 140 150
LYYFTNCFRY ENPQAGRYRE FWQMGSELIG SNKPIADAEV INMAIEGLKE
160 170 180 190 200
INMDFEINIG HLGVLKGVFE KYDLSDDEGN EIRRLIDKED MDGLKSALNR
210 220 230 240 250
IESEKNIEIS EKVFEVLDLK GGREVISKLK EKLAEFESSI AALENLDSIL
260 270 280 290 300
EFVPHEYIIN FGIARGLDYY TGMVFEIYGK REGARQVCGG GRYDNLIELF
310 320 330 340 350
EGEPSPAVGF AYGFDRIMLN IDDFEVEEES IFVVPVKSSD MLLNECLKIA
360 370 380 390 400
KTLREAGKAV ELDLMGRKLN KALNYANTKG IKKVIIVGEN DILEGKVALK
410
NMETGEQSLI ELKDILTI
Length:418
Mass (Da):47,849
Last modified:August 21, 2007 - v1
Checksum:i05EA8EC382B5BD7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR65929.1.
RefSeqiWP_011977246.1. NC_009637.1.
YP_001330080.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR65929; ABR65929; MmarC7_0862.
GeneIDi5329373.
KEGGimmz:MmarC7_0862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA. Translation: ABR65929.1.
RefSeqiWP_011977246.1. NC_009637.1.
YP_001330080.1. NC_009637.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426368.MmarC7_0862.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR65929; ABR65929; MmarC7_0862.
GeneIDi5329373.
KEGGimmz:MmarC7_0862.

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018073.
KOiK01892.
OMAiNMFRYEE.

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-875-MONOMER.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00125. HisZ.
MF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
TIGR00443. hisZ_biosyn_reg. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C7 / ATCC BAA-1331.

Entry informationi

Entry nameiSYH_METM7
AccessioniPrimary (citable) accession number: A6VHK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: April 1, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.