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A6VHK3

- SYH_METM7

UniProt

A6VHK3 - SYH_METM7

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Protein
Histidine--tRNA ligase
Gene
hisS, MmarC7_0862
Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: InterPro
  2. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR426368:GHHL-875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hisS
Ordered Locus Names:MmarC7_0862
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000002298: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Histidine--tRNA ligaseUniRule annotation
PRO_1000016392Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426368.MmarC7_0862.

Structurei

3D structure databases

ProteinModelPortaliA6VHK3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018073.
KOiK01892.
OMAiCGGGNFK.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00125. HisZ.
MF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
TIGR00443. hisZ_biosyn_reg. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6VHK3-1 [UniParc]FASTAAdd to Basket

« Hide

MIMFQKPKGT RDFLPEEMKK RKVIEKKLRK VFDSYNFSEI NTPTFESFEL    50
LSKKTGDEIR TQLFVFKDHG DREMGLRPEL TSSVARFYIN EFKNTPKPVK 100
LYYFTNCFRY ENPQAGRYRE FWQMGSELIG SNKPIADAEV INMAIEGLKE 150
INMDFEINIG HLGVLKGVFE KYDLSDDEGN EIRRLIDKED MDGLKSALNR 200
IESEKNIEIS EKVFEVLDLK GGREVISKLK EKLAEFESSI AALENLDSIL 250
EFVPHEYIIN FGIARGLDYY TGMVFEIYGK REGARQVCGG GRYDNLIELF 300
EGEPSPAVGF AYGFDRIMLN IDDFEVEEES IFVVPVKSSD MLLNECLKIA 350
KTLREAGKAV ELDLMGRKLN KALNYANTKG IKKVIIVGEN DILEGKVALK 400
NMETGEQSLI ELKDILTI 418
Length:418
Mass (Da):47,849
Last modified:August 21, 2007 - v1
Checksum:i05EA8EC382B5BD7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000745 Genomic DNA. Translation: ABR65929.1.
RefSeqiWP_011977246.1. NC_009637.1.
YP_001330080.1. NC_009637.1.

Genome annotation databases

EnsemblBacteriaiABR65929; ABR65929; MmarC7_0862.
GeneIDi5329373.
KEGGimmz:MmarC7_0862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000745 Genomic DNA. Translation: ABR65929.1 .
RefSeqi WP_011977246.1. NC_009637.1.
YP_001330080.1. NC_009637.1.

3D structure databases

ProteinModelPortali A6VHK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426368.MmarC7_0862.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR65929 ; ABR65929 ; MmarC7_0862 .
GeneIDi 5329373.
KEGGi mmz:MmarC7_0862.

Phylogenomic databases

eggNOGi COG0124.
HOGENOMi HOG000018073.
KOi K01892.
OMAi CGGGNFK.

Enzyme and pathway databases

BioCyci MMAR426368:GHHL-875-MONOMER.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00125. HisZ.
MF_00127. His_tRNA_synth.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
[Graphical view ]
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
TIGR00443. hisZ_biosyn_reg. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C7 / ATCC BAA-1331.

Entry informationi

Entry nameiSYH_METM7
AccessioniPrimary (citable) accession number: A6VHK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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