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A6VHK3

- SYH_METM7

UniProt

A6VHK3 - SYH_METM7

Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. histidine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: InterPro
    2. histidyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR426368:GHHL-875-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
    Alternative name(s):
    Histidyl-tRNA synthetaseUniRule annotation
    Short name:
    HisRSUniRule annotation
    Gene namesi
    Name:hisSUniRule annotation
    Ordered Locus Names:MmarC7_0862
    OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
    Taxonomic identifieri426368 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000002298: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Histidine--tRNA ligasePRO_1000016392Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi426368.MmarC7_0862.

    Structurei

    3D structure databases

    ProteinModelPortaliA6VHK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0124.
    HOGENOMiHOG000018073.
    KOiK01892.
    OMAiCGGGNFK.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_00125. HisZ.
    MF_00127. His_tRNA_synth.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    IPR004517. HisZ.
    [Graphical view]
    PANTHERiPTHR11476. PTHR11476. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00442. hisS. 1 hit.
    TIGR00443. hisZ_biosyn_reg. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6VHK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMFQKPKGT RDFLPEEMKK RKVIEKKLRK VFDSYNFSEI NTPTFESFEL    50
    LSKKTGDEIR TQLFVFKDHG DREMGLRPEL TSSVARFYIN EFKNTPKPVK 100
    LYYFTNCFRY ENPQAGRYRE FWQMGSELIG SNKPIADAEV INMAIEGLKE 150
    INMDFEINIG HLGVLKGVFE KYDLSDDEGN EIRRLIDKED MDGLKSALNR 200
    IESEKNIEIS EKVFEVLDLK GGREVISKLK EKLAEFESSI AALENLDSIL 250
    EFVPHEYIIN FGIARGLDYY TGMVFEIYGK REGARQVCGG GRYDNLIELF 300
    EGEPSPAVGF AYGFDRIMLN IDDFEVEEES IFVVPVKSSD MLLNECLKIA 350
    KTLREAGKAV ELDLMGRKLN KALNYANTKG IKKVIIVGEN DILEGKVALK 400
    NMETGEQSLI ELKDILTI 418
    Length:418
    Mass (Da):47,849
    Last modified:August 21, 2007 - v1
    Checksum:i05EA8EC382B5BD7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000745 Genomic DNA. Translation: ABR65929.1.
    RefSeqiWP_011977246.1. NC_009637.1.
    YP_001330080.1. NC_009637.1.

    Genome annotation databases

    EnsemblBacteriaiABR65929; ABR65929; MmarC7_0862.
    GeneIDi5329373.
    KEGGimmz:MmarC7_0862.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000745 Genomic DNA. Translation: ABR65929.1 .
    RefSeqi WP_011977246.1. NC_009637.1.
    YP_001330080.1. NC_009637.1.

    3D structure databases

    ProteinModelPortali A6VHK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426368.MmarC7_0862.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR65929 ; ABR65929 ; MmarC7_0862 .
    GeneIDi 5329373.
    KEGGi mmz:MmarC7_0862.

    Phylogenomic databases

    eggNOGi COG0124.
    HOGENOMi HOG000018073.
    KOi K01892.
    OMAi CGGGNFK.

    Enzyme and pathway databases

    BioCyci MMAR426368:GHHL-875-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_00125. HisZ.
    MF_00127. His_tRNA_synth.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    IPR004517. HisZ.
    [Graphical view ]
    PANTHERi PTHR11476. PTHR11476. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00442. hisS. 1 hit.
    TIGR00443. hisZ_biosyn_reg. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C7 / ATCC BAA-1331.

    Entry informationi

    Entry nameiSYH_METM7
    AccessioniPrimary (citable) accession number: A6VHK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3